Genetic & Genomic MedicinemedRxivPreprint
Enhancer-targeting CRISPR screens at coronary artery disease loci suggest shared mechanisms of disease risk
Markus O Ramste, Chad S. Weldy, Soumya Kundu…·Thomas Quertermous
The paper identifies causal genetic mechanisms at CAD GWAS loci using CRISPR screens and chromatin analysis, revealing enhancer-gene links and ancestry/sex-specific risk factors.