Pharmacology & ToxicologybioRxiv
PI3 kinase inhibitor PI828 uncouples aminergic GPCRs and Ca2+ mobilization irrespectively of its primary target
P. D. Kotova, E. A. Dymova, O. O. Lyamin…·S. S. Kolesnikov
This study shows that the PI3K inhibitor PI828 blocks Ca2+ responses to aminergic agonists through an unknown mechanism unrelated to PI3K inhibition, while wortmannin has minimal effect.
DOI 10.1016/j.bbagen.2024.130649