Allosteric modulation of the adenosine A2A receptor by cholesterol
S. K. Huang, O. Almurad, R. J. Pejana, Z. A. Morrison, A. Pandey, L.-P. Picard, M. Nitz, A. Sljoka, R. S. Prosser
This study shows cholesterol weakly modulates A2AR conformation and signaling through indirect membrane effects rather than direct allosteric binding.
bioRxiv · Sep 13, 2021Biophysics