Author

M. Nitz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Microbiology· 2 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:cell type annotation· 3 Organism:human· 3 Assay:metabolomics· 3 Organism:bacteria (other)· 2 Organism:E. coli· 2 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

P. L. Howell· 4 shared Z. A. Morrison· 3 shared A. Eddenden· 2 shared A. S. Subramanian· 2 shared C. Hunter· 2 shared E. Razvi· 2 shared L. M. Willis· 2 shared R. Pfoh· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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4 shared papersMicrobiology

P. L. Howell

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Structural and functional analysis of Pseudomonas aeruginosa PelA provides insight into the modification of the Pel exopolysaccharide

J. C. Van Loon, F. Le Mauff, M. Vargas, S. Gilbert, R. Pfoh, Z. A. Morrison, E. Razvi, M. Nitz, D. Sheppard, P. L. Howell

This study determines the structure of PelA and shows it modifies Pel through deacetylation and hydrolysis, with PelAB interaction enhancing deacetylation and guiding export.

bioRxiv · Jun 28, 2024Microbiology

The Metabolic Usage and Glycan Destinations of GlcNAz in E. coli

A. Eddenden, M. K. Dooda, Z. A. Morrison, A. S. Subramanian, P. L. Howell, J. M. Troutman, M. Nitz

This paper investigates the metabolic incorporation of GlcNAz into glycans in E. coli, finding it primarily in peptidoglycan with lower levels in PNAG and none in LPS or ECA.

bioRxiv · Aug 17, 2023Biochemistry

Attenuation of polysialic acid biosynthesis in cells by the small molecule inhibitor 8-keto-sialic acid

C. Hunter, Z. Gao, H.-M. Chen, N. Thompson, W. Wakarchuk, m. nitz, S. Withers, L. M. Willis

The paper describes 8-keto-sialic acid as a non-toxic inhibitor that blocks polysialic acid synthesis by terminating chain elongation in cancer and immune cells.

bioRxiv · Sep 2, 2022Biochemistry

A new strategy for identifying polysialylated proteins reveals they are secreted from cancer cells as soluble proteins and as part of extracellular vesicles

C. Hunter, T. Derksen, J. Karathra, K. Baker, M. Nitz, L. M. Willis

This study identifies polysialylated proteins secreted by MCF-7 cancer cells as soluble proteins and extracellular vesicles using a novel metabolic labeling method.

bioRxiv · Sep 1, 2022 · PreprintBiochemistry

Truncation of poly-N-acetylglucosamine (PNAG) polymerization with N-acetylglucosamine analogues

Z. Morrison, A. Eddenden, A. S. Subramanian, P. L. Howell, m. nitz

The paper identifies UDP-GlcNAc analogues that inhibit PNAG polymerization and biofilm formation in E. coli by terminating PNAG chains.

bioRxiv · Oct 13, 2021Biochemistry

Allosteric modulation of the adenosine A2A receptor by cholesterol

S. K. Huang, O. Almurad, R. J. Pejana, Z. A. Morrison, A. Pandey, L.-P. Picard, M. Nitz, A. Sljoka, R. S. Prosser

This study shows cholesterol weakly modulates A2AR conformation and signaling through indirect membrane effects rather than direct allosteric binding.

bioRxiv · Sep 13, 2021Biophysics

PelX is a UDP-N-acetylglucosamine C4-epimerase involved in Pel polysaccharide-dependent biofilm formation

L. S. Marmont, G. B. Whitfield, R. Pfoh, R. J. Williams, T. E. Randall, A. Ostaszewski, E. Razvi, R. A. Groves, H. Robinson, M. Nitz, M. R. Parsek, I. A. Lewis, J. C. Whitney, J. J. Harrison, P. L. Howell

The paper identifies PelX as a UDP-GlcNAc C4-epimerase essential for Pel polysaccharide synthesis and biofilm formation in Pseudomonas protegens.

Journal of Biological Chemistry · Aug 1, 2020Peer-reviewedMicrobiology

Single-Cell Signalling Analysis of Heterocellular Organoids

X. Qin, J. Sufi, P. Vlckova, P. Kyriakidou, S. E. Acton, V. S. W. Li, M. Nitz, C. J. Tape

This study uses mass cytometry to analyze cell-type specific signaling networks in organoids and reveals how genetic mutations mimic stromal cell signaling in cancer organoids.

bioRxiv · Nov 11, 2019Cell Biology