A. Pandey

The HSF-DREB-MYB transcriptional regulatory module regulates flavonol biosynthesis and flavonoid B-ring hydroxylation in banana(Musa acuminata)

This study identifies a transcriptional regulatory module involving MaHSF11 and MaMYBFA factors that regulates flavonol biosynthesis and B-ring hydroxylation in banana.

The Mayo Clinic Salivary Tissue-Organoid Biobanking: A Resource for Salivary Regeneration Research

The paper establishes a salivary regenerative biobank and identifies markers and proteomic signatures of salivary gland stem and progenitor cells.

PP2A catalytic subunit alpha is critically required for CD8+ T cell homeostasis and anti-bacterial responses

This study shows that PP2A catalytic subunit alpha is essential for CD8+ T cell homeostasis and anti-bacterial responses, with Bcl2 rescue limited to spleen.

Wildlife vaccination strategies for eliminating bovine tuberculosis at the wildlife-livestock interface

This study evaluates wildlife vaccination strategies combined with harvest to eliminate bovine tuberculosis in white-tailed deer, finding pulse vaccination effective with moderate coverage and improved when paired with increased harvest.

Designer grass pea for transgene-free minimal neurotoxin-containing seeds with CRISPR-Cas9

This study uses CRISPR-Cas9 to create grass pea plants with minimal neurotoxin {beta}-ODAP in seeds, achieving 99% reduction without transgenes.

Genomic perspectives of SARS CoV-2 in liver disease patients with its clinical correlation: A single centre retrospective study

This study compares the mutational and clinical profiles of liver disease patients infected with different SARS CoV-2 variants, finding higher mortality risk and specific genetic mutations associated with adverse outcomes.

Glucose deprivation promotes pseudo-hypoxia and de-differentiation in lung adenocarcinoma

This study shows glucose deprivation in lung adenocarcinoma causes de-differentiation and an aggressive phenotype through epigenetic changes and HIF1 activation.

Flavonols contrary affect the interconnected glucosinolate and camalexin biosynthesis pathway in Arabidopsis thaliana

This study investigates how flavonol deficiency and supplementation affect gene expression and metabolic pathways in Arabidopsis thaliana seedlings, revealing inverse regulation of camalexin and glucosinolate biosynthesis.

Biochemical analysis of anthocyanin and proanthocyanidin and their regulation in determining chickpea flower and seed coat colours

This study identifies CaMATE1 and CabHLH as regulators of flower and seed coat color in chickpea by manipulating gene expression in a desi genotype.

Interplay between R2R3 MYB-type activators and repressors regulates proanthocyanidin biosynthesis in banana (Musa acuminata)

This study identifies R2R3 MYB activators and repressors that regulate proanthocyanidin biosynthesis in banana, revealing competitive MBW complex formation as a regulatory mechanism.

Ocimum sanctum, OscWRKY1, regulates phenylpropanoid pathway genes and promotes resistance to pathogen infection in Arabidopsis

This study identifies OscWRKY1 from Ocimum sanctum as a regulator of the phenylpropanoid pathway and pathogen resistance in Arabidopsis through direct binding to W-box cis-elements.

AtERF60, negatively regulates ABR1 to modulate basal resistance response in Arabidopsis

This study identifies AtERF60 as a regulator of ABR1, showing that AtERF60 overexpression enhances basal resistance to PstDC3000 while its mutation increases susceptibility.

Diverse pathogens activate the host RIDD pathway to subvert BLOS1-directed immune defense

This study shows that pathogens like Brucella and coronavirus MHV exploit the RIDD pathway to degrade BLOS1, impairing lysosomal trafficking and enhancing their intracellular survival.

Allosteric modulation of the adenosine A2A receptor by cholesterol

This study shows cholesterol weakly modulates A2AR conformation and signaling through indirect membrane effects rather than direct allosteric binding.

The nuclear effector ArPEC25 from the necrotrophic fungus Ascochyta rabiei targets the chickpea transcription factor CaβLIM1a and negatively modulates lignin biosynthesis for host susceptibility

The Ascochyta rabiei effector ArPEC25 enters the host nucleus and targets the transcription factor CaβLIM1a to manipulate phenylpropanoid pathway for negative modulation of chickpea lignin biosynthesis.

Proximity-dependent biotinylation to elucidate the interactome of TNK2 non-receptor tyrosine kinase

This study uses BioID and BioSITe to map TNK2's interactome, identifying known and novel binding partners and validating one with immunoblot.

Interactions between fungal hyaluronic acid and host CD44 promote internalization by recruiting host autophagy proteins to forming phagosomes

This paper shows fungal hyaluronic acid interacts with host CD44 to recruit autophagy proteins to phagosomes, promoting fungal internalization via a Ca2+ -CaMKKβ-AMPK-ULK1 signaling pathway.

Gene loss during a transition to multicellularity

The paper examines gene loss in volvocine algae during multicellular evolution, finding that gene loss drives developmental complexity through novel protein interactions and network reconfiguration.

Aryl hydrocarbon receptor and TGF-β inducible early gene mediate a transcriptional axis modulating immune homeostasis in mosquitoes

This study identifies AhR and TIEG as a transcriptional axis modulating immune homeostasis in mosquitoes, showing their roles in immune response regulation through gene networks involving sugar metabolism and circadian rhythms.

Ligand Modulation of the Conformational Dynamics of the A2A Adenosine Receptor Revealed by Single-Molecule Fluorescence

This study uses single-molecule fluorescence to analyze how ligands modulate conformational dynamics of the A2A adenosine receptor, revealing ligand-dependent changes in state transitions and dynamics.

Lactobacillus rhamnosus attenuates bone loss and maintains bone health by skewing Treg-Th17 cell balance in Ovx mice

This study shows that Lactobacillus rhamnosus reduces bone loss and improves bone health in Ovx mice by modulating Treg and Th17 cell balance and cytokine profiles.

Sero-prevalence and risk factors of leptospirosis in commercial cattle herds of Rupandehi district, Nepal

USP19 modulates cancer cell migration and invasion and acts as a novel prognostic marker in patients with early breast cancer

This study identifies USP19 as a regulator of cancer cell migration and invasion, showing its role as a prognostic marker in early breast cancer.

The mitochondrial carrier SFXN1 is critical for Complex III integrity and cellular metabolism

This study identifies SFXN1 as critical for Complex III integrity and cellular metabolism through its role in heme and central carbon metabolism, independent of its known function as a serine transporter.

Juvenile hormone affects the development and strength of circadian rhythms in young bumble bee (Bombus terrestris) workers

This study shows that juvenile hormone (JH) enhances circadian rhythm strength and development in young bumble bees but does not affect free-running period or locomotor activity.

Systems Biology under heat stress in Indian Cattle

This study compares gene expression under heat stress in two Indian cattle breeds, finding Tharparkar better adapts through upregulated stress response and antioxidant genes.

A Systematic Analysis of Mosquito-Microbiome Biosynthetic Gene Clusters Reveals Antimalarial Siderophores that Reduce Mosquito Reproduction Capacity

The paper identifies antimalarial siderophores from mosquito microbiomes that reduce mosquito reproduction and inhibit Plasmodium parasites.

The R2R3-MYB gene family in banana (Musa acuminata): genome-wide identification, classification and expression patterns

This study identifies and classifies R2R3-MYB genes in banana, revealing their expression patterns and functional clades, providing a foundation for future functional studies and breeding programs.

Protein evolution is structure dependent and non-homogeneous across the tree of life

The paper estimates and compares clade-specific protein evolution models to show non-homogeneous evolution across the tree of life, with structure and population dynamics playing key roles.

Juvenile hormone interacts with multiple factors to modulate aggression and dominance in groups of orphan bumble bee (Bombus terrestris) workers

This study shows that juvenile hormone (JH) positively affects dominance in bumble bees, but dominance hierarchies can also form based on body size and prior experience.