Author

O. Khersonsky

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:protein design· 2 Assay:protein structure· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1 Organism:human· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

S. J. Fleishman· 3 shared B. Breithausen· 1 shared C. de Boer· 1 shared C. Henneberger· 1 shared C. J. Jackson· 1 shared G. J. Davies· 1 shared H. Hirase· 1 shared H. Janovjak· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBiochemistry

S. J. Fleishman

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Stable mammalian serum albumins designed for bacterial expression

O. Khersonsky, M. Goldsmith, I. Zaretsky, S. Hamer-Rogotner, O. Dym, T. Unger, M. Yona, Y. Fridmann-Sirkis, S. J. Fleishman

This paper designs stable mammalian serum albumins for bacterial expression, showing improved thermostability and ligand binding properties.

bioRxiv · Mar 28, 2023Biochemistry

Combinatorial assembly and design of enzymes

R. Lipsh-Sokolik, O. Khersonsky, S. P. Schroder, C. de Boer, S. Y. Hoch, G. J. Davies, H. S. Overkleeft, S. J. Fleishman

The paper introduces CADENZ, a machine-learning strategy for designing structurally diverse enzymes, achieving a tenfold improved hit rate and over 10,000 active enzymes.

bioRxiv · Sep 17, 2022Bioengineering

A computationally designed fluorescent biosensor for D-serine

V. Vongsouthi, J. H. Whitfield, P. Unichenko, J. A. Mitchell, B. Breithausen, O. Khersonsky, L. Kremers, H. Janovjak, H. Monai, H. Hirase, S. J. Fleishman, C. Henneberger, C. J. Jackson

The paper designs a fluorescent biosensor for D-serine by engineering an SBP with improved affinity, specificity, and thermostability, enabling its use in measuring D-serine concentrations in brain slices.

bioRxiv · Aug 18, 2020 · PreprintBiochemistry