O. Dym

An unconventional interaction interface between the peroxisomal targeting factor Pex5 and Eci1 enables PTS1 independent import

The paper identifies an unconventional Pex5-Eci1 interaction interface that enables PTS1-independent peroxisomal import of Eci1 in yeast.

Cathepsin X is a conserved cell death protein involved in algal response to environmental stress

The paper identifies cathepsin X as a conserved cell death protein in algae involved in responses to environmental stress through transcriptome analysis and mutant studies.

The impact of molecular variants, crystallization conditions and space group on structure-ligand complexes: A case study on Bacterial Phosphotriesterase Variants and complexes

This study examines how molecular variants, crystallization conditions, and space group affect the visualization of ligand-bound protein structures, using bacterial phosphotriesterase as a case study.

Stable mammalian serum albumins designed for bacterial expression

This paper designs stable mammalian serum albumins for bacterial expression, showing improved thermostability and ligand binding properties.

Phylogeny and biogeography of the algal DMS-releasing enzyme

The paper identifies and characterizes DLHs in diverse algae, revealing their broader taxonomic distribution and biogeographic patterns, with implications for the marine sulfur cycle.

Allosteric communication between ligand binding domains modulates substrate inhibition in adenylate kinase

This study investigates how AMP substrate inhibition in adenylate kinase is modulated by domain motions, showing that inhibitory concentrations of AMP increase domain closure and affect catalytic activity.

gUMI-BEAR, a modular, unsupervised population barcoding method to track variants and evolution at high resolution

gUMI-BEAR tracks population variants and evolution with high resolution, demonstrating its use in yeast lineage tracking and variant screening.

PGRL1A redox states alleviate photoinhibition in Arabidopsis during step changes in light intensity

This study shows that PGRL1A redox states help Arabidopsis plants adjust to sudden light changes by regulating photosynthetic processes like NPQ and PMF.

SARS-CoV-2 RBD in vitro evolution follows contagious mutation spread, yet generates an able infection inhibitor

The paper shows that in vitro evolved SARS-CoV-2 RBD mutations, like S477N, E484K, and N501Y, correlate with increased infectivity and are inhibited by high-affinity RBD drugs.

Bringing BOS to light: Uncovering the key enzyme in the biosynthesis of the neurotoxin β-ODAP in Grass Pea (Lathyrus sativus L.)

The paper identifies the enzyme BOS responsible for β-ODAP biosynthesis in grass pea, revealing its structure and function after over 50 years of research.

A molecular lid mechanism of K+ channelblocker action revealed by a cone peptide

The paper investigates two cone peptides' mechanisms of blocking K+ channels in Drosophila Shaker, revealing a 'molecular lid' mechanism for one peptide.

Pore-modulating toxins exploit inherent slow inactivation to block K+ channels

The paper shows that the toxin Cs1 blocks K+ channels by modulating pore structure through hydrogen bond disruption, leading to asymmetric pore collapse.