Author

J. A. Mitchell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Pharmacology & Toxicology· 2 Biochemistry· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

B. Ahmetaj-Shala· 4 shared N. S. Kirkby· 4 shared F. Shala· 2 shared P. C. Armstrong· 2 shared A. Joshi· 1 shared A. Papantonis· 1 shared A. Platania· 1 shared B. Breithausen· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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4 shared papersPharmacology & Toxicology

B. Ahmetaj-Shala

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Competition between transcription and loop extrusion modulates promoter and enhancer dynamics

A. Platania, C. Erb, M. Barbieri, B. Molcrette, E. Grandgirard, M. A. de Kort, K. Meaburn, T. Taylor, V. M. Shchuka, S. Kocanova, G. Monteiro Oliveira, J. A. Mitchell, E. Soutoglou, T. L. Lenstra, N. Molina, , T. Sexton

The paper investigates how transcription and loop extrusion interact to influence promoter and enhancer dynamics through live tracking and simulations.

bioRxiv · Apr 25, 2023 · PreprintCell Biology

Tissue fibroblasts are a critical source of prostacyclin and anti-thrombotic

J. A. Mitchell, M. Vinokurova, M. E. Lopes-Pires, F. Shala, P. C. Armstrong, B. Ahmetaj-Shala, Y. Elghazouli, B. Liu, Y. Zhou, C. Hao, H. Herschman, N. S. Kirkby

The paper shows lung and other tissues produce prostacyclin via fibroblasts, providing systemic anti-thrombotic protection, challenging the traditional view that endothelium is the main source.

bioRxiv · Jan 11, 2022 · PreprintPharmacology & Toxicology

Temporal in vivo platelet labelling in mice reveals age-dependent receptor expression and conservation of specific mRNAs

P. C. Armstrong, H. E. Allan, N. S. Kirkby, A. Joshi, C. Gutmann, M. Crescente, J. A. Mitchell, M. Mayr, T. D. Warner

This study uses in vivo temporal labeling to show age-dependent changes in mouse platelet function and mRNA conservation.

bioRxiv · Dec 17, 2021Physiology

Resistance of endothelial cells to SARS-CoV-2 infection in vitro

B. Ahmetaj-Shala, T. P. Peacock, L. Baillon, O. Swann, H. Gashaw, W. S. Barclay, J. A. Mitchell

This study shows that endothelial cells are resistant to SARS-CoV-2 infection due to low ACE2 and TMPRSS2 expression, suggesting vascular dysfunction in COVID-19 arises from inflammatory factors rather than direct viral infection.

bioRxiv · Nov 8, 2020 · PreprintImmunology

A computationally designed fluorescent biosensor for D-serine

V. Vongsouthi, J. H. Whitfield, P. Unichenko, J. A. Mitchell, B. Breithausen, O. Khersonsky, L. Kremers, H. Janovjak, H. Monai, H. Hirase, S. J. Fleishman, C. Henneberger, C. J. Jackson

The paper designs a fluorescent biosensor for D-serine by engineering an SBP with improved affinity, specificity, and thermostability, enabling its use in measuring D-serine concentrations in brain slices.

bioRxiv · Aug 18, 2020 · PreprintBiochemistry

Systemic analysis of putative SARS-CoV-2 entry and processing genes in cardiovascular tissues identifies a positive correlation of BSG with age in endothelial cells

B. Ahmetaj-Shala, R.-K. Vaja, S. S. Atanur, P. M. George, N. S. Kirkby, J. A. Mitchell

The paper analyzes gene expression in cardiovascular tissues to identify age-related correlations with SARS-CoV-2 entry genes, finding increased BSG expression in endothelial cells with age.

bioRxiv · Jun 23, 2020Immunology

Metal-organic framework (MOF) nanomedicine preparations of sildenafil designed for the future treatment of pulmonary arterial hypertension

N. A. Mohamed, H. Abou Saleh, Y. Kameno, I. Marei, G. de Nucci, B. Ahmetaj-Shala, F. Shala, N. S. Kirkby, L. Jennings, R. P. Davies, P. D. Lickiss, J. A. Mitchell

This paper develops a nanomedicine formulation of sildenafil using MIL-89 MOF for controlled release in PAH treatment, showing delayed vasodilation.

bioRxiv · Jul 30, 2019 · PreprintPharmacology & Toxicology