Cleavage Site Specificity for Processing of Farnesylated Prelamin A by the Zinc Metalloprotease ZMPSTE24
T. D. Babatz, E. D. Spear, W. Xu, O. L. Sun, L. Nie, E. P. Carpenter, S. Michaelis
This study identifies sequence requirements for ZMPSTE24 cleavage of prelamin A, revealing preferences for hydrophobic residues at P1 and sensitivity of C-terminal residues.
bioRxiv · Aug 17, 2020Cell Biology