S. Michaelis

Abolishing the prelamin A ZMPSTE24 cleavage site leads to progeroid phenotypes with near-normal longevity in mice

This study shows that mice with permanently farnesylated prelamin A live nearly normal lifespans but show aging-related defects, suggesting prelamin A accumulation contributes to aging phenotypes.

Systematic exploration of Escherichia coli phage-host interactions with the BASEL phage collection

The paper systematically explores Escherichia coli phage-host interactions using a new phage collection, revealing patterns in phage phenotypes and immunity system potency.

Defining Substrate Requirements for Cleavage of Farnesylated Prelamin A by the Integral Membrane Zinc Metalloprotease ZMPSTE24

This study identifies flexible substrate requirements for ZMPSTE24 cleavage of prelamin A using a yeast system, showing that both the C-terminal and N-terminal regions have variable length and composition needs.

Cleavage Site Specificity for Processing of Farnesylated Prelamin A by the Zinc Metalloprotease ZMPSTE24

This study identifies sequence requirements for ZMPSTE24 cleavage of prelamin A, revealing preferences for hydrophobic residues at P1 and sensitivity of C-terminal residues.

A new paradigm for Prelamin A proteolytic processing by ZMPSTE24: the upstream SY^LL cleavage occurs first and there is no CaaX processing by ZMPSTE24

This study challenges the established order of prelamin A processing by ZMPSTE24, showing that SY^LL cleavage occurs first and independently of C-terminal modifications.

ZMPSTE24 Missense Mutations that Cause Progeroid Diseases Decrease Prelamin A Cleavage Activity and/or Protein Stability

This paper identifies ZMPSTE24 missense mutations that impair prelamin A cleavage, classifying them into activity, stability, or dual defects and showing potential therapeutic rescue strategies.