L. Nie

DePARylation is critical for S phase progression and cell survival

This study shows that dePARylation by PARG is essential for S phase progression and cell survival, with PARG inhibition causing cytotoxicity through pADPr accumulation.

Mass spectrometry imaging links interxylary cork formation with phytochemical distribution in Scutellaria baicalensis

This study uses mass spectrometry imaging to show that interxylary cork formation in Scutellaria baicalensis correlates with spatial phytochemical distribution, revealing distinct flavonoid accumulation patterns in different root tissue decay stages.

Shin in the eye: Au-CS@FNDs as contact lens additives for blocking UV irradiation, bacterial keratitis, and corneal neovascularizationtherapies

This paper develops Au-CS@FNDs contact lens additives to block UV, prevent bacterial keratitis, and inhibit corneal neovascularization.

Label-free differential imaging of cellular components in mouse brain tissue by wide-band photoacoustic microscopy

The paper develops a wide-band photoacoustic microscopy system to image cellular components in mouse brain tissue without labeling, revealing phospholipid distribution at 1690 nm.

PRE-CLINICAL IMMUNE RESPONSE AND SAFETY EVALUATION OF THE PROTEIN SUBUNIT VACCINE NANOCOVAX FOR COVID-19

This study evaluates the immune response and safety of the protein subunit vaccine Nanocovax in animal models, showing high immunogenicity and no adverse effects.

The structural basis of fatty acid elongation by the ELOVL elongases

The paper reports the structure of the human ELOVL7 elongase, revealing its catalytic mechanism and substrate-binding sites, with implications for inhibiting VLCFA accumulation in diseases.

Cleavage Site Specificity for Processing of Farnesylated Prelamin A by the Zinc Metalloprotease ZMPSTE24

This study identifies sequence requirements for ZMPSTE24 cleavage of prelamin A, revealing preferences for hydrophobic residues at P1 and sensitivity of C-terminal residues.

Selective Labeling and Identification of the Tumor Cell Proteome of Pancreatic Cancer In Vivo

This study identifies the tumor cell proteome of pancreatic cancer in vivo using BONCAT and DIA-MS, distinguishing it from non-tumor cells in the tumor microenvironment.

A new paradigm for Prelamin A proteolytic processing by ZMPSTE24: the upstream SY^LL cleavage occurs first and there is no CaaX processing by ZMPSTE24

This study challenges the established order of prelamin A processing by ZMPSTE24, showing that SY^LL cleavage occurs first and independently of C-terminal modifications.

Klp2 and Ase1 synergize to maintain meiotic spindle stability during metaphase I

This study compares spindle dynamics in mitosis and meiosis I using fission yeast, showing Klp2 maintains meiotic spindle stability with Ase1, but not mitotic spindles.

Moxifloxacin efficacy against Mycobacterium abscessus in vivo using zebrafish model

This study evaluates moxifloxacin efficacy against Mycobacterium abscessus in a zebrafish model, finding limited in vivo activity despite good in vitro results.

C17orf53 defines a novel pathway involved in inter-strand crosslink repair

This study identifies C17orf53 as a novel gene involved in inter-strand crosslink repair, showing its role in DNA replication and repair factor loading.

ZMPSTE24 Missense Mutations that Cause Progeroid Diseases Decrease Prelamin A Cleavage Activity and/or Protein Stability

This paper identifies ZMPSTE24 missense mutations that impair prelamin A cleavage, classifying them into activity, stability, or dual defects and showing potential therapeutic rescue strategies.