W. Xu

Restoring O-glycosylation and expression of MUC2 limits progression of colorectal cancer

This study shows that restoring MUC2 O-glycosylation and expression via rosiglitazone inhibits colorectal cancer progression by enhancing intestinal barrier function.

Wave succession in the pandemic clone of Vibrio parahaemolyticus driven by gene loss

The paper investigates gene loss in Vibrio parahaemolyticus pandemic clones, showing it drives wave succession through environmental and transmission advantages.

Unraveling MLL1-fusion Leukemia: Epigenetic Revelations from an iPS Cell Point Mutation

This study introduces a point mutation in MLL1 in iPS cells to mimic MLL1F-LSCs phenotypes, revealing that loss of MLL1 enzymatic activity drives H3K4 trimethylation via mislocalized SETd1a.

Origin and stepwise improvement of vertebrate lungs

The paper analyzes single-cell RNA sequencing data to show that lung development involves regulatory changes and new genes, with some features specific to bony fishes and mammals.

Nuclear receptor E75/NR1D2 drives tumor malignant transformation by integrating Hippo and Notch pathways

The paper shows that E75/NR1D2 integrates Hippo and Notch pathways to drive tumor malignancy in response to hormone inhibition.

Genomic evolution reshapes cell type diversification in the amniote brain

The paper creates a single-cell atlas of amniote brains to study cell type diversification and identifies species-specific gene expression patterns and novel cell subtypes.

Electrostatic interactions in nucleosome and higher-order structures are regulated by protonation state of histone ionizable residue

The paper investigates how changes in histone protonation states affect nucleosome electrostatic potentials and interactions with partner proteins, and how cancer mutations influence these interactions.

Horizontally acquired CSP genes contribute to wheat adaptation and improvement

This study identifies horizontally acquired CSP genes in wheat that enhance drought tolerance and photosynthetic efficiency, contributing to wheat adaptation and improvement.

Heterotrimeric Collagen Helix with High Specificity of Assembly Results in a Rapid Rate of Folding

This paper designs a collagen heterotrimer with high folding specificity and reports its faster folding rate compared to other systems.

An epilepsy-associated CILK1 variant compromises KATNIP regulation and impairs primary cilia and Hedgehog signaling

This study shows that a CILK1 variant linked to epilepsy impairs primary cilia and Hedgehog signaling by disrupting KATNIP regulation in mouse cells.

Time-lapse Image Super-resolution Neural Network with Reliable Confidence Quantification for Optical Microscopy

This paper introduces a time-lapse image super-resolution neural network with confidence quantification for optical microscopy, improving temporal consistency and reliability.

Megabarcoding reveals a tale of two very different dark taxa along the same elevational gradient

The paper uses megabarcoding to show that two Diptera taxa have distinct spatio-temporal distributions along an elevational gradient in a temperate forest.

Multiple Omics Find New Cecal Microbial Features Associated with Feed Efficiency in Ducks

The paper identifies microbial and metabolic differences associated with feed efficiency in ducks using metagenomics, transcriptomics, and metabolomics.

A change in the cell wall status initiates the elimination of the nucellus in Arabidopsis

The paper shows that pectin degradation in the cell wall initiates nucellus elimination in Arabidopsis, regulated by TRANSPARENT TESTA 16, and suggests this cell wall change drove seed evolution.

Assessing Spns2-dependent S1P Transport as a Prospective Therapeutic Target

This study evaluates a novel S1P transport blocker, SLF80821178, showing efficacy in multiple sclerosis without the cardiac side effects of SRMs, but with less lymphopenia and unchanged lymph S1P levels.

The dynamin-related protein Dyn2 is essential for both apicoplast and mitochondrial fission in Plasmodium falciparum

This study shows that PfDyn2 is essential for apicoplast and mitochondrial fission in Plasmodium falciparum, leading to cytokinesis failure and developmental defects.

Experimental evolution of a reduced bacterial chemotaxis network

This study uses experimental evolution to test the necessity of chemotaxis pathway components in E. coli, finding that core components are essential but some auxiliary proteins can be compensated for.

Novel Polymycoviruses Are Encapsidated in Filamentous Virions

This paper identifies and characterizes three novel polymycoviruses in phytopathogenic fungi, confirming they are encapsidated in filamentous virions with P-A-S-rich coat proteins.

The segmented flavivirus Alongshan virus reduces mitochondrial mass via degrading STAT2 to suppress innate immune response

Avian influenza virus circulation and immunity in a wild urban duck population prior to and during a highly pathogenic H5N1 outbreak

This study tracks AIV infection and immunity in urban ducks before and during an H5N1 outbreak, finding population-wide infections and waning immunity over time.

Unraveling the gut microbiota of Tibetan chickens: insights into highland adaptation and ecological advantages

This study compares the gut microbiota of Tibetan chickens from different environments to identify adaptations to high-altitude conditions.

Dual-targeted nanoparticulate drug delivery systems for enhancing triple-negative breast cancer treatment

This paper develops a dual-targeted nanoparticulate drug delivery system (SJNP) combining SN38 and JQ-1 to enhance triple-negative breast cancer treatment by disrupting DNA repair and mitochondrial function.

RFX6 at locus 6q22 confers metastasis and drug resistance in prostate cancer

This study identifies RFX6 at locus 6q22 as a driver of prostate cancer metastasis and drug resistance through epigenetic and genetic mechanisms.

Dihydrothiazolo ring-fused 2-pyridone antimicrobial compounds treat Streptococcus pyogenes skin and soft tissue infection

This study develops and tests GmPcides, dihydrothiazolo ring-fused 2-pyridone compounds, showing efficacy against Streptococcus pyogenes SSTI and biofilm formation.

Comprehensive Multi-Omic Analysis Reveals Distinct Molecular Features in Early and Advanced Stages of Hepatocellular Carcinoma

This study uses multi-omic analyses to identify molecular features and biomarkers in early and advanced hepatocellular carcinoma stages.

Hybrid Adipocyte-Derived Exosome Nano Platform for Potent Chemo-Phototherapy in Targeted Hepatocellular Carcinoma

This paper develops a hybrid adipocyte-derived exosome platform for targeted chemo-phototherapy of hepatocellular carcinoma, showing enhanced drug delivery and tumor growth inhibition.

Dysregulation of γδ intraepithelial lymphocytes precedes Crohn's disease-like ileitis

This study identifies dysregulation of γδ intraepithelial lymphocytes (IELs) before the onset of Crohn's disease-like ileitis in a mouse model.

Tip60-mediated Rheb acetylation links palmitic acid with mTORC1 activation and insulin resistance

This study shows that palmitic acid induces mTORC1 activation via Tip60-mediated Rheb acetylation, leading to insulin resistance, while unsaturated fatty acids do not.

Multifunctionality of V-type ATPase during asexual growth and development of Plasmodium falciparum

This study investigates the localization and function of V-type ATPase in Plasmodium falciparum, showing its role in maintaining cytosolic pH and enabling hemoglobin digestion during parasite development.

Eyes on nature: Embedded vision cameras for multidisciplinary biodiversity monitoring

The paper introduces a portable, low-power embedded vision camera system for biodiversity monitoring, demonstrating its application across multiple ecological disciplines with classification accuracies between 55% and 96%.