Parallel evolution and enhanced virulence upon in vivo passage of an RNA virus in Drosophila melanogaster
O. M. Lezcano, L. Fuhrmann, G. Ramakrishnan, N. Beerenwinkel, M. Huynen, R. P. van Rij
This study shows that RNA virus evolution under host immune pressure leads to parallel mutations in a specific viral protein, increasing virulence and replication efficiency across different host genotypes.
bioRxiv · Jul 21, 2023 · PreprintMicrobiology