This study identifies non-canonical genes linked to RAAS overactivation in lethal COVID-19, causing multi-organ damage and mediastinal lymph node dysfunction.

bioRxiv · Oct 8, 2023 · PreprintImmunology

Generative design approach to combine architected Voronoi foams with porous collagen scaffolds to create a tunable composite biomaterial

M. J. Dewey, R. S. Chang, A. V. Nosatov, K. Janssen, S. Crotts, S. Hollister, B. Harley

This paper develops a generative design method to create tunable composite biomaterials by combining Voronoi foams with collagen scaffolds for better mechanical performance and conformal fitting in bone defect repair.

bioRxiv · Sep 5, 2023Bioengineering

A mitochondrial surveillance mechanism activated by SRSF2 mutations in hematologic malignancies

X. Liu, S. A. Devadiga, R. F. Stanley, R. Moroow, K. Janssen, M. Quesnel-Vallieres, O. Pomp, A. A. Moverley, C. Li, N. Skuli, M. P. Carroll, J. Huang, D. C. Wallace, K. W. Lynch, O. Abdel-Wahab, P. S. Klein

This study shows that SRSF2 mutations disrupt mitochondrial mRNA splicing, impair complex I function, and increase mitophagy through a PINK1 splicing mechanism, identifying mitophagy as a therapeutic target in MDS and AML.

bioRxiv · Jun 25, 2023 · PreprintCancer Biology

Arbovirus-vector protein interactomics identifies Loquacious as a co-factor for dengue virus replication in Aedes mosquitoes

B. Besson, O. M. Lezcano, G. J. Overheul, K. Janssen, C. G. Spruijt, M. Vermeulen, J. Qu, R. P. Van Rij

The paper identifies Loquacious as a mosquito host factor essential for dengue and Zika virus replication, revealing its role in viral RNA replication independent of RNAi activity.

bioRxiv · Feb 4, 2022Microbiology