J. Qu

Distinct Escherichia coli transcriptional profiles in the guts of recurrent UTI sufferers revealed by pangenome hybrid selection

This study identifies distinct E. coli transcriptional profiles in the guts of recurrent UTI sufferers using a novel pangenome hybrid selection method.

Proteomics analysis reveals novel phosphorylated residues and associated proteins of the polyomavirus DNA replication initiation complex.

DNA damaged-induced phosphorylation of a viral replicative DNA helicase results in inhibition of DNA replication through attenuation of helicase function

This study shows DDR phosphorylation of SV40 LT at T518 inhibits DNA replication by reducing helicase activity without affecting ATPase function or protein interactions.

Age-associated failure of efficient cardiac proteostatic adaptations to chronic cAMP-stress is associated with accelerated heart aging

This study shows that aging impairs proteostatic mechanisms in mice with cardiac-specific over-expression of adenylyl cyclase VIII, leading to accelerated heart aging and cardiomyopathy.

The aryl hydrocarbon receptor regulates epidermal differentiation through transient activation of TFAP2A

This study shows that AHR activates TFAP2A to regulate epidermal differentiation and barrier function in human keratinocytes.

Pan-cancer analysis reveals tumor microbiome associations with host molecular aberrations

This study identifies associations between tumor microbiomes and host molecular aberrations across 32 cancer types using multi-omics data from TCGA.

Quorum-sensing gene regulates hormetic effects induced by sulfonamides in Comamonadaceae

The paper shows that sulfonamides induce hormesis in Comamonas testosteroni by activating a quorum-sensing gene that enhances nucleotide synthesis for cell proliferation.

Metabolic interplay between Proteus mirabilis and Enterococcus faecalis facilitates polymicrobial biofilm formation and invasive disease

This study identifies a metabolic interaction between Proteus mirabilis and Enterococcus faecalis that enhances biofilm formation and CAUTI severity.

The Hsf1-sHsp cascade has pan-antiviral activity in mosquito cells

The paper identifies the Hsf1-sHsp cascade as a pan-antiviral mechanism in mosquito cells, effective against multiple arboviruses.

Translational control by Trypanosoma brucei DRBD18 contributes to the maintenance of the procyclic state

This study shows that DRBD18 in Trypanosoma brucei regulates translational efficiency of specific transcripts, maintaining the procyclic form by repressing procyclic-specific proteins and enhancing bloodstream/metacyclic-specific proteins.

Intravital microscopy of satellite cell dynamics and their interaction with myeloid cells during skeletal muscle regeneration

This study uses intravital microscopy to examine satellite cell dynamics and interactions with myeloid cells during skeletal muscle regeneration, revealing that direct contact is not required for early activation but is important for proliferation and differentiation.

Angiopoietin-like 4 shapes the intrahepatic T-cell landscape via eIF2α signalingduring steatohepatitis in diet-induced NAFLD.

The paper identifies Angptl4's role in shaping intrahepatic T-cell activation via eIF2α signaling during fibrosis in diet-induced NAFLD.

Development of Equine Polyclonal Antibodies as a Broad-Spectrum Therapy Against SARS-CoV-2 Variants

This paper develops equine polyclonal antibodies that broadly neutralize major SARS-CoV-2 variants, showing high efficacy in vitro and ex vivo with low cost and potential for large-scale production.

Arbovirus-vector protein interactomics identifies Loquacious as a co-factor for dengue virus replication in Aedes mosquitoes

The paper identifies Loquacious as a mosquito host factor essential for dengue and Zika virus replication, revealing its role in viral RNA replication independent of RNAi activity.

The interactome of Cryptococcus neoformans Rmt5 reveals multiple regulatory points in fungal cell biology and pathogenesis

This study identifies Rmt5 as a critical regulator of Cryptococcus neoformans morphology and virulence by characterizing its interactome and phenotypic effects.

Regional Cell Atlas of Human Intestine Shapes Distinct Immune Surveillance

The paper creates a regional cell atlas of human intestine using single-cell RNA sequencing and spatial transcriptomics, revealing how microenvironment shapes immune surveillance and disease susceptibility.

Direct focus sensing and shaping for high-resolution multi-photon imaging in deep tissue

This paper develops an adaptive optics three-photon microscope for high-resolution imaging in deep brain tissue, achieving near-diffraction-limited performance and enabling functional calcium imaging and microsurgery through the intact skull.

The endoplasmic reticulum-resident protein TMEM-120/TMEM120A promotes fat storage in C. elegans and mammalian cells

This study identifies TMEM-120/TMEM120A as a conserved protein that promotes fat storage by enhancing triacylglycerol synthesis and lipid droplet expansion in C. elegans and mammalian cells.

Spike Protein Targeting "Nano-Glue" that Captures and Promotes SARS-CoV-2 Elimination

This paper discovers CIPS nanosheets that selectively bind SARS-CoV-2 spike protein, inhibit viral entry, and promote macrophage-mediated viral elimination.

Resurrection of human endogenous retroviruses during aging reinforces senescence

This study shows that reactivation of human endogenous retroviruses during aging promotes cellular senescence and tissue degeneration, and that blocking this reactivation can alleviate aging.

EZH2 Engages TGFβ Signaling to Promote Breast Cancer Bone Metastasis via Integrin β1-FAK Activation

This study identifies EZH2's role in promoting breast cancer bone metastasis through the integrin β1-FAK pathway and TGFβ signaling.

Incidence and Characteristics of Co-infection and Secondary Infection in Patients with COVID-19

This study examines co-infection and secondary infection rates in COVID-19 patients, finding low rates of Streptococcus pneumoniae co-infections and common secondary pathogens like S. maltophilia.

Nuclear receptor NHR-49 promotes peroxisome proliferation to compensate for aldehyde dehydrogenase deficiency in C. elegans

The paper shows that NHR-49 promotes peroxisome proliferation in C. elegans to compensate for ALH-4 deficiency, which leads to elevated fatty aldehydes and reduced fat storage.

Co-expression of Mitochondrial Genes and ACE2 in Cornea Involved in COVID-19 Infection

The paper identifies a corneal mitochondrial susceptibility module linked to SARS-CoV-2 infection by analyzing co-expression and interaction networks of ACE2 and related genes.

Siderophores provoke extracellular superoxide production by carbon-starving Arthrobacter strains when carbon sources recover

The paper shows that siderophores trigger extracellular superoxide production in carbon-starved Arthrobacter strains when carbon sources recover, and highlights interference of DTPA in superoxide quantification.

Mitochondrial dynamics quantitatively revealed by STED nanoscopy with an enhanced squaraine variant probe

This study uses STED nanoscopy with a new dye to visualize mitochondrial cristae dynamics in live cells at high resolution.

Development of rice conidiation media for Ustilaginoidea virens

This paper develops rice tissue media to enhance conidiation of Ustilaginoidea virens, improving pathogenicity testing and genetic analysis for false smut resistance.

Low-dose IFN-γ induces tumor cell stemness in tumor microenvironment of non-small cell lung cancer

This study shows low-dose IFN-γ promotes tumor stemness in NSCLC via ICAM1-PI3K-Akt-Notch1 pathway, while high-dose IFN-γ induces apoptosis through JAK1-STAT1-caspase pathway.

Rgs12 enhances osteoclastogenesis by suppressing Nrf2 activity and promoting the formation of reactive oxygen species

This study shows Rgs12 promotes osteoclastogenesis by inhibiting Nrf2 and increasing reactive oxygen species.

Precisely control mitochondria with light to manipulate cell fate decision

This paper develops an optogenetic method to control mitochondrial membrane potential and shows its effects on cell fate, finding that light-induced depolarization can induce apoptosis or cytoprotection depending on duration and intensity.