Author

Omer Dushek

Primary ORCID profile (0000-0001-5847-5226 · 10 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Omer DushekiD10 papers · University of Oxford

Biology Disciplines

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Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Citlali Solis Salas· 1 shared Enas Abu-Shah· 1 shared Hong-Sheng Lim· 1 shared Jesse Goyette· 1 shared John Nguyen· 1 shared Jun Allard· 1 shared Marcus Bridge· 1 shared Melissa Lever· 1 shared

Activity by Year

2016-2017 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiophysics

Citlali Solis Salas

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2 papers

Recent·Most cited

Biophysical assay for tethered signaling reactions reveals tether-controlled activity for the phosphatase SHP-1

Jesse Goyette, Citlali Solis Salas, Nicola Coker Gordon, Marcus Bridge, Samuel I Isaacson, Jun Allard, Omer Dushek

The paper develops a biophysical assay to study tethered signaling reactions, revealing that SHP-1 activity is significantly increased by tether binding through allosteric activation and enhanced substrate concentration.

Science Advances · Mar 3, 2017Peer-reviewedBiophysics

Architecture of a minimal signalling pathway explains the T cell response to a 1,000,000-fold variation in antigen affinity and dose

Melissa Lever, Hong-Sheng Lim, Philipp Kruger, John Nguyen, Nicola Trendel, Enas Abu-Shah, Philip K Maini, Philip Anton van der Merwe, Omer Dushek

The paper identifies a minimal signaling model that explains T cell responses across a wide range of antigen affinity and dose variations.

bioRxiv · Aug 27, 2016Immunology