John Nguyen

CCN3-derived peptide BLR-200 impairs YAP activation and attenuates bleomycin-induced skin fibrosis through blocking the generation of Sfrp2-positive fibroblasts

This paper identifies BLR-200, a CCN3-derived peptide, as an anti-fibrotic agent that impairs YAP activation and reduces bleomycin-induced skin fibrosis by blocking Sfrp2-positive fibroblast generation.

Architecture of a minimal signalling pathway explains the T cell response to a 1,000,000-fold variation in antigen affinity and dose

The paper identifies a minimal signaling model that explains T cell responses across a wide range of antigen affinity and dose variations.