Timed STING Inhibition Mitigates Gastrointestinal GvHD While Preserving Graft-versus-Leukemia Activity After Allo-HSCT
Chiara Suriano, Omer Khalid, Paul Heinrich, Kaiji Fan, Sakhila Ghimire, Misbah Tariq, Maria Drießlein, Marianna Maddaloni, Simon Holzinger, Gabriele Inchingolo, Lena Klostermeier, Claudia Gebhard, Nicholas Strieder, Daniela Hirsch, Daniela Weber, , Hendrik Poeck
This study shows that timed STING inhibition reduces gastrointestinal GvHD without affecting GvL in mouse models, suggesting a potential therapeutic strategy for allo-HSCT.
bioRxiv · Jul 21, 2026 · PreprintImmunology