Karin Kleigrewe

This study shows that post-weaning gut microbiota colonization partially restores skeletal muscle but not peripheral nerve abnormalities in germ-free mice.

This study shows that different colorectal cancer genotypes create distinct microbial ecosystems and that microbiota dependence decreases as tumors progress.

This study identifies desaminotyrosine (DAT) as a microbial metabolite that protects against graft-versus-host disease by promoting intestinal regeneration and modulating immune responses.

This study shows dietary fiber reduces TMAO formation after beef consumption, particularly in low meat eaters, by downregulating cutC expression.

The paper quantifies proteins directly interacting with DNA in human cells and identifies key transcription factors and DNA damage proteins in response to treatments.

This study shows that high-fat diets promote GEAC by altering the microbiota-Bile Acid axis and inhibiting FXR, with FXR agonists like OCA slowing disease progression.

This study examines sex-specific effects of early life stress on fear memory and amygdala metabolism, revealing sex-dependent changes in glutamate and metabolic pathways.

This study shows that pentanoate, a microbial postbiotic, is metabolized to citrate, which influences T cell differentiation and anti-cancer CAR T cell efficacy through epigenetic mechanisms.

This study investigates metabolic changes during skeletal muscle hypertrophy using metabolomics and finds rewiring of glycolytic intermediates into anabolic pathways, particularly the serine synthesis pathway.

This study shows that microbiota and metabolite rhythmicity develops early in life, influenced by diet and breastfeeding, with GOS-supplemented formula promoting bifidobacteria.

This study shows that the intestinal clock influences microbiome oscillations and host metabolism, with dietary fiber playing a key role in linking circadian rhythms to metabolic health.

This study identifies a neuronal thermostat mechanism in C. elegans that coordinates membrane fluidity across tissues in response to temperature changes.