Author

Orian Stapleton

Johns Hopkins University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 2 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:software / tool· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

Dmitrijs LvovsiD· 2 shared Elana Judith FertigiD· 2 shared Luciane Tsukamoto KagoharaiD· 2 shared Alexander V. FavoroviD· 1 shared Amanda L. HuffiD· 1 shared Amanda PoissonnieriD· 1 shared André ForjaziD· 1 shared Andrew AdeyiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBioinformatics

Dmitrijs LvovsORCID

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Author profile →

3 papers

Recent·Most cited

STAPLE: automating spatial transcriptomics analysis and AI interpretation

Dmitrijs Lvovs, Jeffrey Quinn, André Forjaz, Ivette Santana-Cruz, Orian Stapleton, Kranthi Vavikolanu, Meredith Wetzel, Demystifying Pancreatic Cancer Therapies TeamLab, Data Science Teamlab, Vincent Bernard, Brian R. Herb, Alexander V. Favorov, Luciane Tsukamoto Kagohara, Ashley L Kiemen, Anirban Maitra, , Elana Judith Fertig

STAPLE automates spatial transcriptomics analysis by integrating multiple tools into a modular framework and provides AI-driven interpretation of results.

bioRxiv · Apr 1, 2026 · PreprintBioinformatics

Differential cell signaling testing for cell-cell communication inference from single-cell data by dominoSignal

Jacob T. Mitchell, Orian Stapleton, Kavita Krishnan, Sushma Nagaraj, Dmitrijs Lvovs, Christopher Cherry, Amanda Poissonnier, Wesley R. Horton, Andrew Adey, Varun Rao, Amanda L. Huff, Jacquelyn W. Zimmerman, Luciane Tsukamoto Kagohara, Neeha Zaidi, Lisa M. Coussens, , Elana Judith Fertig

The paper introduces dominoSignal, a software tool that statistically tests differential cell signaling from single-cell data to infer changes in cell-cell communication networks.

Bioinformatics · Feb 26, 2026Peer-reviewedBioinformatics

Functional genomic dissection of MS risk loci reveals convergence of cis and trans gene regulatory mechanisms in microglia

Michael D. Gallagher, Xochitl Luna, Wenjuan Du, Kathryn E.A. Hazel, Moritz List, Zeynep Aydin, Orian Stapleton, Yiran Cheng, Bingbing Yuan, Keya Viswanathan, Heather R. Keys, George W. Bell, Dheeraj Malhotra, Richard A. Young, Rudolf Jaenisch, Olivia Corradin

The paper identifies cis and trans gene regulatory mechanisms in microglia linked to multiple sclerosis risk SNPs using computational and CRISPR perturbation approaches.

medRxiv · Jun 16, 2025 · PreprintGenetic & Genomic Medicine