Cancer BiologybioRxivPreprint
Tumor-specific draining lymph node CD8 T cells orchestrate an anti-tumor response to neoadjuvant PD-1 immune checkpoint blockade
Rachel Honigsberg, Tatiana Cruz, Liron Yoffe…·Jonathan Villena‐Vargas
This study identifies two transcriptionally distinct CD8 T cell populations in tumor-draining lymph nodes that are shaped by neoadjuvant chemoimmunotherapy and influence tumor and blood T cell environments.