Author

P. Acedo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:drug response / drug discovery· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

J. Zawacka-Pankau· 3 shared A. Fernandes· 1 shared A. Inga· 1 shared A. Kawiak· 1 shared A. Kostecka· 1 shared A. Sznarkowska· 1 shared L. Jiang· 1 shared M. Lion· 1 shared

Activity by Year

2018-2019 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 19 mutual co-author links

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3 shared papersCancer Biology

J. Zawacka-Pankau

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3 papers

Recent·Most cited

Protoporphyrin IX is a dual inhibitor of p53/MDM2 and p53/MDM4 interactions and induces apoptosis in B-cell chronic lymphocytic leukaemia cells

L. Jiang, N. Malik, P. Acedo, J. Zawacka-Pankau

This study shows that Protoporphyrin IX inhibits p53/MDM2 and p53/MDM4 interactions, stabilizes p53 and TAp73, and induces apoptosis in B-cell chronic lymphocytic leukaemia cells without harming normal cells.

bioRxiv · Feb 13, 2019Cancer Biology

Activation of TAp73 and inhibition of thioredoxin reductase for improved cancer therapy in TP53 mutant pancreatic tumors

P. Acedo, A. Fernandes, J. Zawacka-Pankau

This paper identifies PpIX and BPD as compounds that activate TAp73 and inhibit TrxR1, inducing apoptosis in pancreatic cancer cells through a drug-repurposing approach.

bioRxiv · Sep 4, 2018Cancer Biology

Reactivation of TAp73 tumor suppressor by protoporphyrin IX, a metabolite of aminolevulinic acid, induces apoptosis in TP53-deficient cancer cells

A. Sznarkowska, A. Kostecka, A. Kawiak, P. Acedo, M. Lion, A. Inga, J. Zawacka-Pankau

The paper shows that protoporphyrin IX stabilizes and activates TAp73, inducing apoptosis in TP53-deficient cancer cells by disrupting interactions with MDM2/MDMX and inhibiting degradation by Itch.

bioRxiv · Aug 15, 2018Cancer Biology