N. Malik

The atypical cadherin FAT1 is a novel regulator of STAT1, driving its pro-tumorigenic effect via the STAT1/PDCD4 axis in glioblastoma

This study identifies STAT1 as a downstream mediator of FAT1, showing it suppresses PDCD4 to drive pro-tumorigenic effects in glioblastoma.

In silico Antibody-Peptide Epitope prediction for Personalized cancer therapy

This paper develops an in-silico method to predict patient-specific antibody-peptide epitopes using deep learning on a novel multiplex data structure, achieving high F1-scores with minimal data.

PKCβ facilitates leukemogenesis in chronic lymphocytic leukaemia by promoting constitutive BCR-mediated signaling

This study shows PKCβ promotes CLL by enhancing BCR signaling and identifies SP1 as a regulator of PKCβ expression in leukemogenesis.

Intrinsic disorder in CENP-ACse4 tail and its chaperone facilitates synergistic association for kinetochore stabilization

This study investigates the interaction between the disordered Cse4 N-tail and its chaperone Scm3, showing how their synergistic association facilitates kinetochore stabilization through electrostatic interactions and reduced disorder.

MAIT cells have a negative impact on glioblastoma

The paper identifies MAIT cells as immunosuppressive in glioblastoma, correlating their presence with poor patient survival and immune suppressive gene upregulation.

mTORC1 activity is essential for disease progression in chronic lymphocytic leukemia

This study shows that mTORC1 is essential for CLL progression in mice, with rapamycin effectively targeting eEF2 to inhibit proliferation and MCL1 expression.

Strategies for identifying dynamic regions in protein complexes: flexibility changes accompany methylation in chemotaxis receptor signaling states

This study identifies dynamic regions in bacterial chemoreceptors by comparing methylated and unmethylated states using solid-state NMR, revealing flexibility changes in methylation helices.

Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44

This study identifies novel SGK3 substrates, including endosomal proteins, through phosphoproteomic screens and shows SGK3 specifically phosphorylates these proteins at sites distinct from Akt.

Protoporphyrin IX is a dual inhibitor of p53/MDM2 and p53/MDM4 interactions and induces apoptosis in B-cell chronic lymphocytic leukaemia cells

This study shows that Protoporphyrin IX inhibits p53/MDM2 and p53/MDM4 interactions, stabilizes p53 and TAp73, and induces apoptosis in B-cell chronic lymphocytic leukaemia cells without harming normal cells.