Attenuation of homeostatic signaling from apoptotic thymocytes triggers a global regenerative response in the thymus
S. Kinsella, C. A. Evandy, K. Cooper, L. Iovino, P. C. deRoos, K. S. Hopwo, D. W. Granadier, C. W. Smith, S. Rafii, J. A. Dudakov
This study identifies a pathway involving NOD2 and miR29c that, when attenuated, triggers regenerative responses in the thymus after acute damage, enhancing T cell recovery.
bioRxiv · Aug 31, 2020 · PreprintImmunology