K. Cooper

Immunocompetent murine model of Ewing sarcoma reveals role for TGFβ inhibition to enhance immune infiltrates in Ewing tumors during radiation

The paper develops an immunocompetent mouse model of Ewing sarcoma to show that TGFβ inhibition enhances immune infiltration and reduces metastasis during radiation therapy.

Bacterial diversity and composition on the rinds of specific melon cultivars and hybrids from across different growing regions in the United States

This study characterizes bacterial diversity on melon rinds across US regions and identifies regional influences on microbiome composition.

De novo purine metabolism is a metabolic vulnerability of cancers with low p16 expression

This study identifies de novo purine metabolism as a vulnerability in cancers with low p16 expression, showing sensitivity to anti-folate drugs like methotrexate.

Polyploidy enhances desiccation tolerance in the grass Microchloa caffra

This study examines the relationship between polyploidy and desiccation tolerance in the resurrection grass Microchloa caffra, finding that polyploid plants are more desiccation tolerant.

Damage-induced pyroptosis drives endogenous thymic regeneration viainduction of Foxn1 by purinergic receptor activation

The paper identifies that damage-induced pyroptosis of thymocytes, mediated by purinergic receptor activation and Foxn1 upregulation, drives thymic regeneration after acute injury.

Age-related epithelial defects limit thymic function and regeneration

The paper identifies age-related thymic epithelial cell states that impair thymic regeneration and immune function through spatial and single-cell transcriptomics.

Activation of the Zinc-sensing receptor GPR39 promotes T cell reconstitution after hematopoietic stem cell transplant

Utilization efficiency of human milk oligosaccharides by human-associated Akkermansia is strain-dependent

This study examines how different Akkermansia strains utilize human milk oligosaccharides (HMOs) with varying efficiency, showing strain-dependent growth and metabolite production.

Secondary ossification center induces and protects growth plate structure

This study identifies the secondary ossification center's role in protecting growth plate hypertrophic chondrocytes from mechanical stress during terrestrial adaptation.

Attenuation of homeostatic signaling from apoptotic thymocytes triggers a global regenerative response in the thymus

This study identifies a pathway involving NOD2 and miR29c that, when attenuated, triggers regenerative responses in the thymus after acute damage, enhancing T cell recovery.

Snx4-mediated nucleophagy targets transcription factors controlling ATG gene expression

The paper identifies a novel nucleophagy pathway mediated by Snx4 that targets transcription factors regulating ATG gene expression, enabling fine-tuned autophagic responses.

Dynamic aqueous multiphase reaction system for simple, sensitive and quantitative one-pot CRISPR-Cas12a based molecular diagnosis

This paper introduces a dynamic aqueous multiphase reaction system for rapid, sensitive, and quantitative CRISPR-Cas12a-based molecular diagnosis of HPV16/18 DNA.

Clinical Characterization of Host Response to Simian Hemorrhagic Fever Virus Infection in Permissive and Refractory Hosts: A Model for Determining Mechanisms of VHF Pathogenesis

This paper compares host responses to SHFV infection in patas and rhesus monkeys, identifying overlapping and species-specific cytokine and immune cell changes that may drive hemorrhagic fever pathogenesis.