Long-lived rodents reveal signatures of positive selection in genes associated with lifespan and eusociality
A. Sahm, M. Bens, K. Szafranski, S. Holtze, M. Groth, M. Goerlach, C. Calkhoven, C. Mueller, M. Schwab, H. A. Kestler, A. Cellerino, H. Burda, T. Hildebrandt, P. Dammann, M. Platzer
The paper identifies genes under positive selection in long-lived rodents, linking them to mTOR-related processes, immune function, and antioxidant defense, and finds expression patterns consistent with antagonistic pleiotropy in aging.
bioRxiv · Oct 8, 2017Evolutionary Biology