P. Danthi

Cholesterol-Dependent Membrane Deformation by Metastable Viral Capsids Facilitates Entry

This study shows that reovirus capsids deform host membranes in a cholesterol-dependent manner, leading to membrane rupture and viral entry.

Proteasome activity is required for reovirus entry into cells

This study shows that proteasome activity is required for reovirus entry, as proteasome inhibition blocks infection after ISVP formation but before transcriptional activation.

The reovirus σ1 attachment protein influences the stability of its entry intermediate

This study investigates how the reovirus σ1 protein affects the stability of its entry intermediate, finding that σ1 properties influence ISVP stability both through and independently of its encapsidation level.

Early events in reovirus infection influence induction of innate immune response

This study shows that reovirus entry routes and uncoating dynamics influence host immune detection, with faster entry mutants evading immune response.

The reovirus σ3 protein inhibits NF-κB-dependent antiviral signaling

This paper identifies a second mechanism by which reovirus inhibits NF-κB-dependent antiviral signaling through the σ3 protein, which reduces expression of NF-κB target genes without affecting IKK levels or activity.

A CRISPR-Cas9 screen reveals a role for WD repeat-containing protein 81 (WDR81) in the entry of late penetrating viruses

This study uses a CRISPR-Cas9 screen to identify WDR81 as a host factor required for late penetrating virus entry, showing it promotes endosomal maturation and viral replication.

The M2 Gene Is a Determinant of Reovirus-Induced Myocarditis

This study shows that the M2 gene from reovirus strain T3D, when substituted into T1L genetic background, causes lethal myocarditis in mice by enhancing viral replication and inflammation.

Reovirus σ3 protein limits interferon expression and cell death induction

This study shows that reovirus σ3 protein reduces interferon production and necroptosis by mechanisms unrelated to its dsRNA binding ability.

Reovirus core proteins {lambda}1 and σ2 promote stability of disassembly intermediates and influence early replication events

This paper investigates the role of reovirus core proteins {lambda}1 and {sigma}2 in capsid stability and early replication, finding that mismatched core and outer capsid proteins lead to reduced stability and altered replication efficiency.

Loss of IKK subunits limits NF-κB signaling in reovirus infected cells

This study shows that reovirus infection inhibits NF-κB signaling by reducing IKK complex components, thereby blocking gene expression and promoting viral replication.

Cell entry-independent role for the reovirus μ1 protein in regulating necroptosis and the accumulation of viral gene products

This study investigates the role of reovirus μ1 protein in regulating necroptosis and viral gene product accumulation, finding that its absence enhances necroptosis and viral RNA/protein levels.

Selection and characterization of a reovirus mutant with improved thermostability

This paper identifies mutations that enhance reovirus thermostability and characterizes their effects on capsid integrity and replicative fitness.

Protein mismatches caused by reassortment influence functions of the reovirus capsid

This study shows that protein mismatches from reassortment affect reovirus capsid function by altering ISVP* formation and infectivity.

The reovirus μ1 protein contributes to the environmental stability of virions

This study investigates the role of reovirus σ1 in virion stability, showing that σ1 rearrangements and a hyperstable variant contribute to heat resistance.