Author

P. Friedhoff

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:E. coli· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

C. Laffeber· 2 shared V. Kunetsky· 2 shared A. Borsellini· 1 shared A. Quessada-Vial· 1 shared C. Duboc· 1 shared E. Sahin· 1 shared G. Brouwer· 1 shared H. H. Winterwerp· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersBiochemistry

C. Laffeber

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3 papers

Recent·Most cited

DNA mismatch and damage detection using a FRET-based assay for monitoring the loading of multiple MutS sliding clamps

V. Kunetsky, O. Storozhuk, G. Brouwer, C. Laffeber, M. S. Dillingham, J. Lebbink, P. Friedhoff

The paper develops a FRET-based assay using MutS to detect DNA mismatches and damage by monitoring ATP-dependent loading of multiple MutS sliding clamps.

bioRxiv · Jul 23, 2021 · PreprintBiochemistry

Cryo-EM structures reveal how ATP and DNA binding in MutS coordinate the sequential steps of DNA mismatch repair

A. Borsellini, V. Kunetsky, P. Friedhoff, M. H. Lamers

The paper presents cryo-EM structures of Escherichia coli MutS at different stages of the ATP hydrolysis cycle, revealing how ATP binding and hydrolysis induce conformational changes that coordinate DNA mismatch repair.

bioRxiv · Jun 3, 2021Biochemistry

The unstructured linker arms of MutL enable GATC site incision beyond roadblocks during initiation of DNA mismatch repair

Y. S. Mardenborough, K. Nitsenko, C. Laffeber, C. Duboc, E. Sahin, A. Quessada-Vial, H. H. Winterwerp, T. K. Sixma, R. Kanaar, P. Friedhoff, T. R. Strick, J. H. Lebbink

The paper shows that the disordered linker regions of MutL enable bypass of roadblocks during DNA mismatch repair initiation, allowing incision at GATC sites.

bioRxiv · Nov 5, 2018Biochemistry