Author

A. Borsellini

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:E. coli· 2 Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:comparative / phylogenetic analysis· 1 Assay:cryo-EM· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

M. Lamers· 2 shared B. M. Crowley· 1 shared C. E. Barry· 1 shared D. B. Olsen· 1 shared D. F. Warner· 1 shared G. L. Abrahams· 1 shared H. I. M. Boshoff· 1 shared J. Ambler· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

M. Lamers

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A four-point molecular handover during Okazaki maturation

M. Botto, A. Borsellini, M. Lamers

The paper reveals a four-point molecular handover mechanism during Okazaki fragment maturation in E. coli, showing how DNA polymerases, endonuclease, and ligase coordinate to remove RNA primers.

bioRxiv · Aug 2, 2022Biochemistry

DNA-dependent binding of nargenicin to DnaE1 inhibits replication in Mycobacterium tuberculosis

M. D. Chengalroyen, M. K. Mason, A. Borsellini, R. Tassoni, G. L. Abrahams, S. Lynch, Y.-M. Ahn, J. Ambler, K. Young, B. M. Crowley, D. B. Olsen, D. F. Warner, C. E. Barry, H. I. M. Boshoff, M. Lamers, V. Mizrahi

This study shows nargenicin binds to Mtb DnaE1 DNA-dependent polymerase, inhibiting replication and inducing DNA damage response in tuberculosis bacteria.

bioRxiv · Oct 27, 2021Microbiology

Cryo-EM structures reveal how ATP and DNA binding in MutS coordinate the sequential steps of DNA mismatch repair

A. Borsellini, V. Kunetsky, P. Friedhoff, M. H. Lamers

The paper presents cryo-EM structures of Escherichia coli MutS at different stages of the ATP hydrolysis cycle, revealing how ATP binding and hydrolysis induce conformational changes that coordinate DNA mismatch repair.

bioRxiv · Jun 3, 2021Biochemistry