Pharmacology & ToxicologybioRxiv
Demonstration of a common DPhe7 to DNal(2')7 peptide ligand antagonist switch for the melanocortin-3 and melanocortin-4 receptors identifies systematic mischaracterization of the pharmacological properties of melanocortin peptides
L. E. Gimenez, T. A. Noblin, S. Y. Williams…·R. D. Cone
The paper identifies a systematic mischaracterization of melanocortin peptide pharmacology by showing DNal(2)7 residues act as antagonists, not agonists, for MC3R and MC4R.
DOI 10.1021/acs.jmedchem.1c01295