PhysiologybioRxiv
Molecular mechanisms underlying enhanced hemichannel function of a cataract-associated Cx50 mutant
J.-J. Tong, U. Khan, B. G. Haddad…·L. Ebihara
This paper investigates the functional and structural properties of a cataract-associated Cx50 mutant, showing it causes enhanced hemichannel currents and cytotoxicity through altered voltage-gating and electrostatic interactions.
DOI 10.1016/j.bpj.2021.11.004