Evaluating the fitness of PA/I38T-substituted influenza A viruses with reduced baloxavir susceptibility in a competitive mixtures ferret model
L. Y. Lee, J. Zhou, P. Koszalka, R. Frise, R. Farrukee, K. Baba, S. Miah, T. Shishido, M. Galiano, T. Hashimoto, S. Omoto, T. Uehara, E. Mifsud, N. Collinson, K. Kuhlbusch, , A. C. Hurt
The paper evaluates the fitness of baloxavir-resistant influenza A viruses in ferrets, finding reduced within-host fitness for A/H3N2 I38T and lower between-host fitness for A/H1N1pdm09 I38T compared to wild-type viruses.
bioRxiv · Sep 28, 2020Microbiology