Author

R. Farrukee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 2 Organism:human· 1 Approach:statistical model· 1 Organism:virus· 1

Frequent Co-Authors

A. C. Hurt· 3 shared P. C. Reading· 2 shared A. E. Zarebski· 1 shared B. Clinch· 1 shared E. Mifsud· 1 shared J. D. Bloom· 1 shared J. M. McCaw· 1 shared J. Zhou· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersMicrobiology

A. C. Hurt

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3 papers

Recent·Most cited

Predicting potentially permissive substitutions that improve the fitness of A(H1N1)pdm09 viruses bearing the H275Y NA substitution

R. Farrukee, V. Gunalan, S. Maurer-Stroh, P. C. Reading, A. C. Hurt

This study predicts and validates permissive mutations that could restore fitness to oseltamivir-resistant A(H1N1)pdm09 viruses with the H275Y NA substitution.

bioRxiv · Mar 21, 2021 · PreprintMicrobiology

Evaluating the fitness of PA/I38T-substituted influenza A viruses with reduced baloxavir susceptibility in a competitive mixtures ferret model

L. Y. Lee, J. Zhou, P. Koszalka, R. Frise, R. Farrukee, K. Baba, S. Miah, T. Shishido, M. Galiano, T. Hashimoto, S. Omoto, T. Uehara, E. Mifsud, N. Collinson, K. Kuhlbusch, , A. C. Hurt

The paper evaluates the fitness of baloxavir-resistant influenza A viruses in ferrets, finding reduced within-host fitness for A/H3N2 I38T and lower between-host fitness for A/H1N1pdm09 I38T compared to wild-type viruses.

bioRxiv · Sep 28, 2020Microbiology

Characterization of influenza B virus variants with reduced neuraminidase inhibitor susceptibility

R. Farrukee, A. E. Zarebski, J. M. McCaw, J. D. Bloom, P. C. Reading, A. C. Hurt

This study characterizes two influenza B virus variants with NAI resistance, finding H273Y reduces fitness more than D197N in vivo, while D197N remains prevalent in surveillance.

bioRxiv · Sep 4, 2018Microbiology