P. Kruger

Differential impact of TNFRSF co-stimulation on CD8+ T cell cytokine production by feedback control of surface receptor expression

This study investigates how different TNFRSF co-stimulation receptors affect CD8+ T cell cytokine production, revealing that feedback control of surface receptor expression explains their differential impact.

Human CD8+ T cells exhibit a shared antigen threshold for different effector responses

The paper shows that different effector responses of human CD8+ T cells share a common antigen threshold across varying affinities and co-stimulatory conditions.

Perfect adaptation of CD8+ T cell responses to constant antigen input over a wide range of affinity is overcome by costimulation

The paper shows that partial TCR downregulation in T cells leads to perfect adaptation to constant antigen stimulation, which can be overcome by costimulation.