M. Kutuzov

The paper uses CombiCells to compare T cell antigen sensitivity mediated by TCRs, CARs, and BiTEs and assess the impact of co-stimulation and co-inhibition receptors.

The paper evaluates TcE formats to determine how contact distance and flexibility affect their potency in forming immunological synapses.

This study shows that CARs have lower antigen sensitivity than TCRs due to inefficient use of accessory receptors, and demonstrates ways to improve this sensitivity.

The paper measures ultra-low TCR/pMHC affinities and finds T cells have low discriminatory power, requiring large affinity differences to trigger responses.

This study examines how PARP1 and PARP2 regulate BER enzymes in the nucleosomal context, finding PARP1 suppresses enzyme activity while PARP2 affects DNA sealing and modulates Pol{beta} and LigIII.

This study measures the molecular reach of PD-1 tethered SHP-1 complexes and shows how tethering affects substrate accessibility and enzyme activity.

The paper shows that different effector responses of human CD8+ T cells share a common antigen threshold across varying affinities and co-stimulatory conditions.