ImmunologybioRxiv
Perfect adaptation of CD8+ T cell responses to constant antigen input over a wide range of affinity is overcome by costimulation
N. C. Trendel, P. Kruger, S. Gaglione…·O. Dushek
The paper shows that partial TCR downregulation in T cells leads to perfect adaptation to constant antigen stimulation, which can be overcome by costimulation.
DOI 10.1126/scisignal.aay9363