Tumor cell-intrinsic HFE drives glioblastoma growth
K. M. Troike, D. J. Silver, P. K. Ghosh, E. E. Mulkearns-Hubert, C. G. Hubert, J. R. Connor, P. L. Fox, B. W. Kristensen, J. Lathia
This study shows that HFE promotes glioblastoma growth by regulating iron homeostasis and oxidative stress, with HFE loss inducing apoptosis and extending survival.
bioRxiv · Apr 13, 2022 · PreprintCancer Biology