J. Jia

Noncanonical roles of ATG5 and membrane atg8ylation in retromer assembly and function

This study shows ATG5 and membrane atg8ylation regulate retromer function in GLUT1 trafficking, independent of canonical autophagy.

A mechanism that transduces lysosomal damage signals to stress granule formation for cell survival

The paper identifies a calcium-dependent pathway involving ALIX that links lysosomal damage to stress granule formation, promoting cell survival in response to various stressors.

The novel nematicide chiricanine A suppresses Bursaphelenchus xylophilus pathogenicity in Pinus massoniana by inhibiting Aspergillus and its secondary metabolite, sterigmatocystin

Preclinical Basis of the Efficacy and Pharmacodynamics of Finotonlimab, a Humanized Anti-PD-1 Monoclonal Antibody with Potent Implications for Clinical Benefit

This paper evaluates the preclinical efficacy and pharmacodynamics of Finotonlimab, a humanized anti-PD-1 antibody, showing high PD-1 binding affinity and sustained receptor occupancy in cynomolgus monkeys.

Integrated single-nucleus and spatial transcriptomics captures transitional states in soybean nodule symbiosis establishment

The paper integrates single-nucleus and spatial transcriptomics to map transitional states in soybean nodule symbiosis, identifying functionally distinct cell subgroups and a transitional infected cell subtype.

Plant Intron Splicing Efficiency Database (PISE): exploring splicing of ~1,650,000 introns in Arabidopsis, maize, rice and soybean from ~57,000 public RNA-seq libraries

The paper creates a database of intron splicing efficiency across multiple plant species using public RNA-seq data to explore how splicing varies with treatments and genetic mutants.

Palatal morphology predicts the paleobiology of early salamanders

This study shows that palatal morphology in early salamanders reflects ecological preferences and life history strategies, with significant evolutionary changes before the Middle Jurassic.

A live attenuated influenza virus-vectored intranasal COVID-19 vaccine provides rapid, prolonged, and broad protection against SARS-CoV-2 infection

This study develops an intranasal vaccine against SARS-CoV-2 using an influenza virus vector and shows it provides rapid, prolonged, and broad protection against multiple variants in hamsters.

A novel mechanism of Euonymine inhibits in-stent restenosis through enhancing contractile phenotype of VSMCs by targeting AKT1 and p38MAPK

Profiles of Expression pattern and tissue distribution of host defense peptides genes in different chicken (Gallus gallus) breeds related to body weight

The paper examines HDP gene expression and tissue distribution in different chicken breeds, finding correlations between body weight, age, and HDP expression in immune organs and intestine.

Repopulating Kupffer Cells Originate Directly from Hematopoietic Stem Cells

This study shows that repopulating Kupffer cells in adult mice originate directly from hematopoietic stem cells, not from preexisting Kupffer cells or monocytes.

Inducing highly physiologically relevant phenotypes of human vascular smooth muscle cells via 3D printing

This study uses 3D printing to create vessel architectures that induce more physiologically relevant phenotypes in vascular smooth muscle cells compared to 2D cultures.

The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations

The paper examines how somatic cancer mutations in ASCC2 and ASCC3 affect their interaction, reducing affinity and potentially impacting DNA repair.

Protein S-nitrosylation of Human Cytomegalovirus pp71 inhibits its ability to limit STING antiviral responses

The paper identifies protein S-nitrosylation of HCMV pp71 as a host mechanism that reduces its ability to inhibit STING antiviral responses, thereby limiting viral spread.

Bifunctional enzyme SpoT is involved in biofilm formation of Helicobacter pylori with multidrug resistance by upregulating efflux pump Hp1174 (gluP)