A CANCER PERSISTENT DNA REPAIR CIRCUIT DRIVEN BY MDM2, MDM4 (MDMX), AND MUTANT P53 FOR RECRUITMENT OF MDC1 AND 53BP1 TO CHROMATIN
V. Ellison, A. Polotskaia, P. Leybengrub, W. Qiu, R. Lee, R. C. Hendrickson, W. Hu, J. Bargonetti
This study identifies a cancer persistent DNA repair circuit involving mtp53, MDM2, and MDMX that recruits 53BP1 and MDC1 to chromatin, enhancing cell survival.
bioRxiv · Jan 20, 2024Cancer Biology