W. Qiu

Promoted Read-through and Mutation Against Pseudouridine-CMC by an Evolved Reverse Transcriptase

The paper develops a method called Mut-Psi-seq to map pseudouridine at base-resolution using an evolved reverse transcriptase and chemical labeling, revealing new Psi sites in human rRNAs.

How does the ion concentration affect the functions of kinesin BimC

This study investigates how ion concentration affects BimC's function by analyzing electrostatic interactions between BimC and microtubules using molecular dynamics simulations.

A CANCER PERSISTENT DNA REPAIR CIRCUIT DRIVEN BY MDM2, MDM4 (MDMX), AND MUTANT P53 FOR RECRUITMENT OF MDC1 AND 53BP1 TO CHROMATIN

This study identifies a cancer persistent DNA repair circuit involving mtp53, MDM2, and MDMX that recruits 53BP1 and MDC1 to chromatin, enhancing cell survival.

IOBR2: Multidimensional Decoding Tumor Microenvironment for Immuno-Oncology Research

IOBR2 is a tool for analyzing tumor microenvironment using multi-omics data, offering modules for preprocessing, estimation, interaction analysis, and visualization.

Kinesin-14 HSET and KlpA are non-processive microtubule motors with load-dependent power strokes

This study investigates the force generation and motility of Kinesin-14 motors HSET and KlpA, revealing they are non-processive motors with load-dependent power strokes and cooperative behavior.

A Synthetic Dynamic PVA Photoresin for Fast Volumetric Bioprinting of Functional Ultrasoft Hydrogel Constructs

This paper introduces a dynamic PVA photoresin for fast volumetric bioprinting of functional ultrasoft hydrogel constructs, enabling 3D cell growth and matrix mineralization.

Stability of SARS-CoV-2 in cold-chain transportation environments and the efficacy of disinfection measures

This study investigates how cold-chain conditions and disinfection methods affect SARS-CoV-2 stability, finding that low temperature and seawater increase viral survival while LED light and airflow reduce it.

Detection of Borrelia garinii in the USA

The paper reports the first detection of Borrelia garinii in the southeastern United States in rodents and identifies its phylogenetic relationship to European and Far Eastern strains.

Development of recombinant monoclonal antibodies targeting conserved VlsE epitopes in Lyme disease pathogens

This study develops recombinant monoclonal antibodies targeting conserved VlsE epitopes in Lyme disease pathogens, showing they react strongly with human and rabbit sera and are promising for diagnostics and therapeutics.

Cholesterol in the cargo membrane reduces kinesin-1 binding to microtubules in the presence of tau

The paper investigates how cholesterol in a cargo membrane affects kinesin-1 binding to microtubules in the presence of tau, showing that cholesterol enhances tau's inhibitory effect.

Photoclick Phase-separating Hydrogels for 3D Cell Culture and Volumetric Bioprinting

This paper introduces a photoclick resin for creating cell-compatible macroporous hydrogels via PIPS, enabling fast 3D cell culture and volumetric bioprinting with tunable pore sizes.

Molecular mechanisms governing circulating immune cell heterogeneity across different species revealed by single cell sequencing

This study uses single-cell RNA-sequencing to analyze immune cell diversity across 12 species, revealing conserved and divergent molecular mechanisms and cellular interactions.

Tomographic Volumetric Bioprinting of Heterocellular Bone-like Tissues in Seconds

This paper demonstrates tomographic volumetric bioprinting of bone-like tissues with human mesenchymal stem cells and endothelial cells, showing enhanced osteogenic differentiation in 3D co-cultures.

Following the Trail of One Million Genomes: Footprints of SARS-CoV-2 Adaptation to Humans

This study analyzes one million SARS-CoV-2 genomes to identify human-adaptive mutations and develop a simulator to predict viral evolution under different models.

Maximum Antigen Diversification in a Lyme Bacterial Population and Evolutionary Strategies to Overcome Pathogen Diversity

The paper shows evolution-based synthetic antigen designs can overcome pathogen diversity by generating broadly reactive OspC analogs against Lyme disease strains.

Single-cell screening of SARS-CoV-2 target cells in pets, livestock, poultry and wildlife

The paper screens SARS-CoV-2 target cells across 11 animal species using single-cell transcriptomes, finding higher proportions in cats and detecting them in multiple pig cell types.

CoV Genome Tracker: tracing genomic footprints of Covid-19 pandemic

CoV Genome Tracker tracks SARS-CoV-2 genomic changes using haplotype networks and provides evolutionary rates to support pandemic response.

The Orphan Kinesin PAKRP2 Achieves Processive Motility Via Noncanonical Stepping

This study shows that PAKRP2, an orphan kinesin in Arabidopsis, moves processively along microtubules using a noncanonical stepping mechanism with small steps and lateral movements.

A draft reference genome sequence for Scutellaria baicalensis Georgi

The paper reports a draft reference genome sequence for Scutellaria baicalensis using Illumina and PacBio sequencing, providing a foundation for studying its bioactive compound biosynthesis.

The Association between Alcohol Consumption and Telomere Length: A Meta-Analysis Focusing on Observational Studies

This paper conducts a meta-analysis of observational studies to assess the association between alcohol consumption and telomere length, finding a significant link with variability across study types and populations.

Identification and quantification of Lyme pathogen strains by deep sequencing of outer surface protein C (ospC) amplicons

The paper develops a deep sequencing method to identify and quantify Lyme pathogen strains by analyzing the ospC gene in ticks, revealing mixed infections and a new strain related to Borreliella bissettiae.

The preprophase band-associated kinesin-14 OsKCH2 is a processive minus-end-directed microtubule motor

This study identifies OsKCH2 as a processive minus-end-directed kinesin-14 in plants, compensating for the absence of cytoplasmic dynein.