Mechanism of glycoform specificity and protection against antibody dependent enhancement by an anti-afucosylated IgG nanobody
A. Gupta, K. S. Kao, R. Yamin, D. A. Oren, Y. Golgur, J. Du, P. Lollar, E. Sundberg, J. V. Ravetch
This paper presents the X-ray structure of a nanobody that binds afucosylated IgG1 Fc and disrupts pathogenic interactions, rescuing mice in a dengue model.
bioRxiv · Jan 23, 2023 · PreprintImmunology