J. Du

A Combination of Machine Learning and PBPK Modeling Approach for Pharmacokinetics Prediction of Small Molecules in Humans

This paper combines machine learning and PBPK modeling to predict small molecule pharmacokinetics in humans without experimental data, achieving higher accuracy than traditional methods.

Evaluate the efficiency of Mr BMT in macrophage replacement of peripheral organs

This study evaluates Mr BMT's efficiency in replacing macrophages in peripheral organs, finding comparable replacement efficiencies to traditional BMT in liver, kidney, lung, and spleen.

The dual resistance mechanism of CYP325G4 and CYP6AA9 in Culex pipiens pallens legs according to transcriptome and proteome analysis

This study identifies CYP325G4 and CYP6AA9 as key P450 enzymes involved in deltamethrin resistance in Culex pipiens legs through transcriptome and proteome analysis.

Metabolic phenotyping of healthy and diseased human RPE cells

This study identifies nutrient utilization differences between healthy and diseased human RPE cells, showing reduced metabolic flexibility in SFD RPE and the impact of differentiation on nutrient use.

OCA-B/Pou2af1 is sufficient to promote CD4+ T cell memory and prospectively identifies memory precursors

This study shows that OCA-B expression promotes CD4+ T cell memory and identifies memory precursor cells using a reporter mouse line.

A Vascular Dissection and Rupture Linked Metabolite Acts Via BLT2 Receptor

This study identifies 12-HETE as a key metabolite in thoracic aortic dissection (TAD) that activates BLT2 receptors on macrophages, driving inflammation and VSMC phenotype switching, and shows that targeting this pathway can reduce TAD progression.

Visualizing chaperone-mediated multistep assembly of the human 20S proteasome

The paper uses cryo-EM to visualize the assembly of the human 20S proteasome, revealing how chaperones and propeptides guide subunit incorporation and proteasome activation.

Tissue Inhibitor of Metalloproteinase 3 (TIMP3) mutations increase glycolytic activity and dysregulate glutamine metabolism in RPE cells

This study shows that TIMP3 mutations in RPE cells increase glycolytic activity and disrupt glutamine metabolism, linking these changes to Sorsbys Fundus Dystrophy.

Inhibition of KLK8 promotes pulmonary endothelial repair by restoring VE-cadherin/Akt/FOXM1 pathway

This study shows that inhibiting KLK8 restores the VE-cadherin/Akt/FOXM1 pathway, promoting endothelial repair and reducing sepsis-induced lung injury and mortality.

TIPE drives a cancer stem-like phenotype by promoting glycolysis via PKM2/HIF-1alpha axis in melanoma

This study shows TIPE promotes glycolysis and stemness in melanoma by interacting with PKM2 and activating HIF-1α through phosphorylation.

Photobody formation spatially segregates two opposing phytochrome B signaling actions to titrate plant environmental responses

The paper shows that phytochrome B forms photobodies to spatially separate and balance opposing effects on PIF5, enabling environmentally sensitive regulation of plant responses.

The circadian clock regulates PIF3 protein stability in parallel to red light

This study identifies a circadian clock-regulated ubiquitin ligase, CFH1, that targets PIF3 for degradation, linking the circadian clock to photomorphogenic growth through protein stability.

Human Pannexin 1 Channel is NOT Phosphorylated by Src Tyrosine Kinase at Tyr199 and Tyr309

This study shows that commercially available antibodies for detecting PANX1 tyrosine phosphorylation are nonspecific and that Src does not phosphorylate these sites in heterologous systems.

Cooperative progression of colitis and leukemia modulated by clonal hematopoiesis via PTX3/IL-1β; pro-inflammatory signaling

This study shows that clonal hematopoiesis driven by TET2 mutations interacts with inflammatory signals like PTX3/IL-1β to promote colitis and leukemia through a gut-bone marrow axis.

DEC1 is an adult clock regulator that links circadian rhythms to functional β-cell maturation

This study shows DEC1 regulates circadian rhythms in β-cells, linking them to metabolic maturation and glucose responsiveness.

Defining Vaginal Community Dynamics: daily microbiome transitions, the role of menstruation, bacteriophages and bacterial genes

This study classifies vaginal microbiome dynamics into four types using daily samples and identifies factors like phage abundance and bacterial strains that influence these dynamics.

Hypoxia Bi-directionally Regulates Gut Vascular Barrier through HIF-1α-dependent Mechanism in vitro

Oxaliplatin-induced cardiotoxicity in mice is connected to the changes in energy metabolism in the heart tissue

This study shows that chronic oxaliplatin treatment in mice causes metabolic shifts in heart tissue, leading to cardiotoxicity and potential diagnostic and therapeutic targets.

Cataloging the Phylogenetic Diversity of Human Bladder Bacterial Isolates

This paper presents a bladder-specific bacterial reference collection of 1134 genomes to study the human bladder microbiota and its interactions with the host.

Proline provides a nitrogen source in the retinal pigment epithelium to synthesize and export amino acids for the neural retina

This study shows the retinal pigment epithelium uses proline nitrogen to produce and export amino acids to the neural retina, highlighting its role in retinal metabolism.

Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution

This paper investigates a TRPM2 chanzyme from choanoflagellates, revealing how its enzymatic and channel functions are coupled through structural and kinetic mechanisms.

The maize PLASTID TERMINAL OXIDASE (PTOX) gene controls the carotenoid content of kernels.

This study identifies ZmPTOX1 as a key gene for carotenoid biosynthesis in maize kernels, showing that its disruption reduces carotenoid content while overexpression increases it, particularly beta-carotene.

Confinement with Myosin-II suppression increases heritable loss of chromosomes, using live-cell ChReporters

The paper uses live-cell ChReporters to show that Myosin-II suppression in confined mitosis increases heritable chromosome loss, independent of spindle assembly checkpoint in 3D and 2D.

Mechanism of glycoform specificity and protection against antibody dependent enhancement by an anti-afucosylated IgG nanobody

This paper presents the X-ray structure of a nanobody that binds afucosylated IgG1 Fc and disrupts pathogenic interactions, rescuing mice in a dengue model.

Tissue-specific sex difference in mouse eye and brain metabolome under fed and fasted states

This study identifies tissue-specific and state-dependent sex differences in metabolomes of mouse eye and brain tissues under fed and fasted conditions.

Evolutionary transcriptomics reveals longevity mostly driven by polygenic and indirect selection in mammals

This study uses comparative transcriptomics across mammals to show that longevity is influenced by polygenic and indirect selection, with key pathways like insulin signaling showing correlations with lifespan.

Engineered reporter phages for rapid detection of Escherichia coli, Klebsiella spp., and Enterococcus spp. in urine

This study develops a rapid phage-based diagnostic assay to detect E. coli, Klebsiella spp., and Enterococcus spp. in urine with high sensitivity and specificity within 5 hours.

A Visual, Inexpensive, and Wireless Capillary Rheometer

This paper introduces a low-cost, wireless capillary rheometer for visualizing and measuring rheological properties of complex fluids.

Contact Stiffness Provides a Unified Frame of Reference for Understanding the Effects of Extracellular Matrix Mechanics on Cell Behaviors

The paper introduces contact stiffness as a framework to quantify how ECM mechanics influence cell behaviors, showing its correlation with YAP activity and stem cell differentiation.

Reduced Neutralization of SARS-CoV-2 Omicron Variant in Sera from SARS-CoV-1 Survivors after 3-dose of Vaccination

This study shows that SARS-CoV-1 survivors vaccinated with ZF2001 have reduced neutralization against SARS-CoV-2 Omicron compared to other variants.