Time-of-day defines the efficacy of NAD+ to treat diet-induced metabolic disease by adjusting oscillations of the hepatic circadian clock
Q. Escalante-Covarrubias, L. Mendoza-Viveros, M. Gonzalez-Suarez, F. Becerril-Perez, I. Pacheco-Bernal, E. Carreno-Vazquez, P. Mass-Sanchez, M. Bustamante-Zepeda, R. Orozco-Solis, L. Aguilar-Arnal
This study shows that the time of day affects the effectiveness of NAD+ therapy for diet-induced metabolic disease in mice by influencing hepatic circadian rhythms.
bioRxiv · Aug 12, 2022 · PreprintPhysiology