The Glycan-Specificity of the Pineapple Lectin AcmJRL and its Carbohydrate-Dependent Binding of the SARS-CoV-2 Spike Protein
J. Meiers, J. Dastbaz, S. Adam, S. Rasheed, S. H. Kirsch, P. Meiser, P. Gross, R. Mueller, A. Titz
This study identifies high-mannose glycans as the preferred ligands for AcmJRL and shows its carbohydrate-dependent binding to the SARS-CoV-2 spike protein with a low micromolar KD.
bioRxiv · May 27, 2022 · PreprintBiophysics