R. Mueller

3D-bioprinted patient-specific organotypic bone model mimicking mineralization dysregulation in FKBP10-related osteogenesis imperfecta

The paper uses 3D-bioprinted bone models to show dysregulated mineralization in FKBP10-related osteogenesis imperfecta compared to healthy controls.

Combined physical and pharmacological anabolic osteoporosis therapies increase bone response and mechanoregulation in female mice

This study shows that combining physical and pharmacological anabolic therapies improves bone strength and mechanoregulation in female mice with osteoporosis.

Daily rhythms in metabolic and locomotor behaviour of prematurely ageing PolgA mice

This study examines daily metabolic and locomotor rhythms in prematurely ageing PolgA mice, finding sex-specific differences in activity and metabolic patterns.

Unveiling Frailty: Comprehensive and Sex-Specific Characterization in Prematurely Aging PolgA Mice

This study characterizes frailty in PolgA mice, showing sex-specific differences and parallels to human aging.

Thermo-amplifier circuit in probiotic E. coli for stringently temperature-controlled release of a novel antibiotic

The paper develops a thermo-amplifier circuit in probiotic E. coli to control the release of darobactin, a peptide antibiotic, at 40°C while maintaining low leakiness at 37°C.

Time series of chicken stool metagenomics and egg metabolomics in changing production systems

The paper examines how changing chicken production systems affects gut microbiota and egg metabolites over three weeks, finding significant changes in taxa and metabolomic profiles.

Insights into the biosynthesis of icumazole unveiling a distinctive family of crotonyl-CoA carboxylase/reductase

The paper identifies a novel family of crotonyl-CoA carboxylase/reductase (CCR) enzymes involved in icumazole biosynthesis, revealing unique substrate specificity and cofactor usage.

The Glycan-Specificity of the Pineapple Lectin AcmJRL and its Carbohydrate-Dependent Binding of the SARS-CoV-2 Spike Protein

This study identifies high-mannose glycans as the preferred ligands for AcmJRL and shows its carbohydrate-dependent binding to the SARS-CoV-2 spike protein with a low micromolar KD.

Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria

The paper analyzes biosynthetic gene clusters in entomopathogenic nematode-symbiotic bacteria to identify conserved and unique natural products and their functional roles.

The mycobacterial mutasome: composition and recruitment in live cells

This study identifies the molecular composition and function of the mycobacterial mutasome, showing that the ImuB-{beta} clamp interaction is essential for mutagenic DNA repair in mycobacteria.

Tomographic Volumetric Bioprinting of Heterocellular Bone-like Tissues in Seconds

This paper demonstrates tomographic volumetric bioprinting of bone-like tissues with human mesenchymal stem cells and endothelial cells, showing enhanced osteogenic differentiation in 3D co-cultures.

Diversity and prevalence of colibactin- and yersiniabactin encoding mobile genetic elements in enterobacterial populations: insights into evolution and co-existence of two bacterial secondary metabolite determinants

The paper investigates the diversity and prevalence of colibactin and yersiniabactin encoding elements in enterobacteria, finding species-specific lineages and horizontal gene transfer mechanisms.

Nature of active forces in tissues: how contractile cells can form extensile monolayers

The paper investigates how epithelial cell monolayers switch from extensile to contractile behavior as intercellular contacts weaken, revealing mechanotransductive responses and implications for cell sorting and tissue dynamics.

The sandarazols are cryptic and structurally unique plasmid encoded toxins from a rare myxobacterium

This paper identifies and characterizes a new plasmid-encoded toxin family, the sandarazols, from a myxobacterium, revealing their biosynthetic pathway and antimicrobial activity.

Effects of early life stress on bone homeostasis in mice and humans

This study examines the effects of early life stress on bone homeostasis in mice and humans, finding catabolic bone changes associated with stress-related factors.

Biosynthesis of cittilins, unusual ribosomally synthesized and post-translationally modified peptides from Myxococcus xanthus

This paper identifies cittilins as a new RiPP family natural product from Myxococcus xanthus and characterizes their biosynthesis and potential biological function.

The Digital Mouse: why computational modelling of mouse models of disease can improve translation

The paper argues for developing computational models of mouse disease models to improve translation to clinical applications, proposing the Digital Mouse framework and a Digital Mouse Frailty Index as examples.

Scaffold pore geometry guides gene regulation and bone-like tissue formation in dynamic cultures

This study shows that scaffold pore geometry and dynamic mechanical cues influence osteoblast differentiation and bone-like tissue formation in vitro.

Ribosome-targeting antibiotics impair T cell effector function and ameliorate autoimmunity by blocking mitochondrial protein synthesis

Evaluation of longitudinal time-lapsed in vivo micro-CT for monitoring fracture healing in mouse femur defect models

This study evaluates longitudinal in vivo micro-CT for monitoring fracture healing in mice, finding no significant impact on callus formation or remodeling from repeated scans.

Discovery of a polybrominated aromatic secondary metabolite from a planctomycete points at an ambivalent interaction with its macroalgae host

The paper identifies a polybrominated secondary metabolite from a planctomycete and suggests it has an ambivalent role in its macroalgae host interaction.

Microbial community-level features linked to divergent carbon flows during early litter decomposition in a constant environment

The paper links microbial community-level features to carbon flow patterns in litter decomposition using soil samples from the southwestern United States.

Sustained oscillations of epithelial cell sheets

This study identifies a novel mode of collective oscillations in epithelial cell sheets under confinement, showing that oscillatory motion drives cellular movements and is regulated by confinement dimensions and force transmission.

Watching antibiotics in action: Exploiting time-lapse microfluidic microscopy as a tool for target-drug interaction studies in Mycobacterium

This paper uses microfluidic microscopy to study how antibiotics affect DNA replication in Mycobacterium smegmatis at the single-cell level, revealing distinct mechanisms of action for three replication inhibitors.