Author

S. Adam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 2 Cell Biology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:cell type annotation· 3 Research Focus:chromatin & epigenetic regulation· 3 Assay:DNA methylation· 2 Approach:genetic perturbation / CRISPR· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

D. Durocher· 3 shared S. E. Rossi· 3 shared A. Alvarez-Quilon· 2 shared H. Melo· 2 shared J. Dastbaz· 2 shared M. De Marco Zompit· 2 shared M. Stucki· 2 shared N. Hustedt· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersCancer Biology

D. Durocher

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Nuclear lamin A-associated proteins are required for centromere assembly

A. Landeros, D. Wallace, A. Rahi, C. Magdongon, P. Suraneni, M. Amin, M. Chakraborty, S. Adam, D. Foltz, D. Varma

This study shows that Lamin A-associated proteins are essential for centromere assembly during mitotic exit by interacting with centromere and kinetochore proteins.

bioRxiv · Sep 25, 2023 · PreprintCell Biology

The Glycan-Specificity of the Pineapple Lectin AcmJRL and its Carbohydrate-Dependent Binding of the SARS-CoV-2 Spike Protein

J. Meiers, J. Dastbaz, S. Adam, S. Rasheed, S. H. Kirsch, P. Meiser, P. Gross, R. Mueller, A. Titz

This study identifies high-mannose glycans as the preferred ligands for AcmJRL and shows its carbohydrate-dependent binding to the SARS-CoV-2 spike protein with a low micromolar KD.

bioRxiv · May 27, 2022 · PreprintBiophysics

The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis

M. De Marco Zompit, C. Mooser, S. Adam, S. E. Rossi, A. Jeanrenaud, P.-A. Leimbacher, D. Fink, D. Durocher, M. Stucki

This study identifies CIP2A as a mitosis-specific protein that forms a complex with TOPBP1 to regulate DSB repair and chromosomal stability during mitosis.

bioRxiv · Feb 8, 2021Cell Biology

CIP2A is a prime synthetic-lethal target for BRCA-mutated cancers

S. Adam, S. E. Rossi, N. Moatti, M. De Marco Zompit, T. F. Ng, A. Alvarez-Quilon, J. Desjardins, V. Bhaskaran, G. Martino, D. Setiaputra, S. M. Noordermeer, T. K. Ohsumi, N. Hustedt, R. K. Szilard, N. Chaudhary, , D. Durocher

The paper identifies CIP2A as a synthetic-lethal target in BRCA-mutated cancers by showing its essential role in mitotic chromosome stability and its interaction with TOPBP1.

bioRxiv · Feb 8, 2021 · PreprintCancer Biology

Biosynthesis of cittilins, unusual ribosomally synthesized and post-translationally modified peptides from Myxococcus xanthus

J. J. Hug, J. Dastbaz, S. Adam, O. Revermann, J. Koehnke, D. Krug, R. Mueller

This paper identifies cittilins as a new RiPP family natural product from Myxococcus xanthus and characterizes their biosynthesis and potential biological function.

bioRxiv · May 25, 2020Biochemistry

A genetic map of the response to DNA damage in human cells

M. Olivieri, T. Cho, A. Alvarez-Quilon, K. Li, M. J. Schellenberg, M. Zimmermann, N. Hustedt, S. E. Rossi, S. Adam, H. Melo, A. M. Heijink, G. Sastre-Moreno, N. Moatti, R. Szilard, A. McEwan, , D. Durocher

The paper identifies 840 genes involved in the DNA damage response through CRISPR/Cas9 screens and highlights specific gene functions in DNA repair and toxicity mechanisms.

bioRxiv · Nov 18, 2019Cancer Biology

Mutations of R882 in DNMT3A change flanking sequence preferences and cellular methylation patterns in AML

M. Emperle, S. Adam, S. Kunert, M. Dukatz, A. Baude, C. Plass, P. Rathert, P. Bashtrykov, A. Jeltsch

This study shows that DNMT3A R882 mutations alter flanking sequence preferences and methylation patterns, leading to hypermethylation and gene misregulation in AML.

bioRxiv · Aug 1, 2019Biochemistry