Sensitization to Ionizing Radiation by MEK inhibition is Dependent on SNAI2 in Fusion-negative Rhabdomyosarcoma
N. R. Hensch, K. Bondra, L. Wang, P. Sreenivas, X. R. Zhao, P. Modi, A. V. Vaseva, P. J. Houghton, M. S. Ignatius
This study shows that MEK inhibition sensitizes fusion-negative rhabdomyosarcoma to ionizing radiation via SNAI2 downregulation, leading to increased apoptosis and tumor regression.
bioRxiv · May 2, 2022Cancer Biology