Author

P. Sreenivas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

M. S. Ignatius· 3 shared K. Bondra· 2 shared L. Wang· 2 shared N. R. Hensch· 2 shared P. J. Houghton· 2 shared X. R. Zhao· 2 shared A. V. Vaseva· 1 shared B. D. Sunkel· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersCancer Biology

M. S. Ignatius

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3 papers

Recent·Most cited

The 3D chromatin landscape of rhabdomyosarcoma

M. Wang, P. Sreenivas, B. D. Sunkel, L. D. Wang, M. S. Ignatius, B. Stanton

This study maps the 3D chromatin structure of rhabdomyosarcoma subtypes using Hi-C, revealing structural variations and gene regulatory patterns.

NAR Cancer · Jun 9, 2023Peer-reviewedCancer Biology

Sensitization to Ionizing Radiation by MEK inhibition is Dependent on SNAI2 in Fusion-negative Rhabdomyosarcoma

N. R. Hensch, K. Bondra, L. Wang, P. Sreenivas, X. R. Zhao, P. Modi, A. V. Vaseva, P. J. Houghton, M. S. Ignatius

This study shows that MEK inhibition sensitizes fusion-negative rhabdomyosarcoma to ionizing radiation via SNAI2 downregulation, leading to increased apoptosis and tumor regression.

bioRxiv · May 2, 2022Cancer Biology

SNAI2-mediated direct repression of BIM protects rhabdomyosarcoma from ionizing radiation

L. Wang, N. R. Hensch, K. Bondra, P. Sreenivas, X. R. Zhao, J. Chen, K. Baxi, R. M. Campos, B. Gryder, S. Pomella, R. Rota, E. Y. Chen, J. Khan, P. J. Houghton, M. S. Ignatius

This study identifies SNAI2 as a repressor of BIM, protecting rhabdomyosarcoma from ionizing radiation through a P53-independent mechanism.

bioRxiv · Jan 25, 2021Cancer Biology