GIV/Girdin and Exo70 Constitute the Core of the Mammalian Polarized Exocytic Machinery
C. Rohena, N. Rajapakse, I.-C. Lo, P. Novick, D. Sahoo, P. Ghosh
This paper identifies GIV/Girdin as the mammalian homolog of yeast Bem1p, showing it binds Exo70 and is essential for polarized exocytosis, matrix metalloprotease delivery, and cell invasion.
bioRxiv · Dec 9, 2019Cell Biology