D. Sahoo

Molecular Signatures for Microbe-Associated Colorectal Cancers

The paper identifies a Microbe-Associated Colorectal Cancer Signature (MACS) induced by Fusobacterium nucleatum in genetically predisposed hosts, linking microbial infection to early CRC initiation.

Scavenger receptor class B type I is required for efficient glucose uptake and metabolic homeostasis in adipocytes

This study shows that SR-BI is necessary for efficient glucose uptake and metabolic homeostasis in adipocytes, as its absence leads to reduced glucose uptake and altered lipid metabolism.

A Living Organoid Biobank of Crohn's Disease Patients Reveals Molecular Subtypes for Personalized Therapeutics

This paper creates a biobank of patient-derived organoids to identify molecular subtypes of Crohn's disease and test subtype-specific therapies.

Coupling of NOD2 to GIV is Required for Bacterial Sensing

This paper identifies GIV as a NOD2-interactor that enhances bacterial sensing and signaling in macrophages, revealing how loss of function in the NOD2 1007fs variant impairs protective immune responses.

AI-assisted Discovery of an Ethnicity-influenced Driver of Cell Transformation in Esophageal and Gastroesophageal Junction Adenocarcinomas

The paper uses AI to identify a racially influenced immune driver of esophageal and gastroesophageal junction adenocarcinomas, showing its absence in African Americans and association with neutrophil processes and genetic variants.

Phenotypic dissection of epithelial lineages and therapeutic manipulation of differentiation programs in human Adenoid Cystic Carcinomas

This study identifies cell-surface markers to isolate distinct cell types in ACC, shows myoepithelial-like cells as progenitors of ductal-like cells, and demonstrates RA signaling modulation as a therapeutic strategy.

COVID-19 lung disease shares driver AT2 cytopathic features with Idiopathic pulmonary fibrosis

This study identifies shared cellular and molecular features between severe COVID-19 and idiopathic pulmonary fibrosis, highlighting ER stress and AT2 cell dysfunction as key drivers.

CULTURE AND MAINTENANCE OF URINE-DERIVED, 3-DIMENSIONAL CANINE TRANSITIONAL CELL CARCINOMA ORGANOIDS

This study establishes urine-derived 3D canine TCC organoids as a model to study bladder cancer ex vivo, showing similar RNA biomarker expression and greater cisplatin sensitivity compared to 2D human TCC cells.

GIV/Girdin, a Non-receptor Modulator for Gαi/s, Regulates Spatiotemporal Signaling during Sperm Capacitation and is Required for Male Fertility

This study shows GIV/Girdin regulates spatiotemporal signaling during sperm capacitation and is essential for male fertility by modulating distinct signaling programs in sperm tail and head.

SPT6 loss Permits the Transdifferentiation of Keratinocytes into an Intestinal Fate that Recapitulates Barrett's Metaplasia

The paper shows that SPT6 loss in keratinocytes leads to transdifferentiation into an intestinal fate, mimicking Barrett's metaplasia and linking acid exposure to metaplastic progression.

An AI-guided signature reveals the nature of the shared proximal pathways of host immune response in MIS-C and Kawasaki disease

The paper identifies shared and divergent immune pathways in MIS-C and Kawasaki disease using gene signatures and clinical data.

Adult Stem Cell-derived Complete Lung Organoid Models Emulate Lung Disease in COVID-19

This study develops a human lung organoid model to emulate COVID-19 pathogenesis, showing proximal airway cells drive viral infection while distal cells drive excessive immune response.

Evolution of Modularity, Interactome and Functions of GIV/Girdin (CCDC88A) from Invertebrates to Vertebrates

The paper examines the evolutionary changes in GIV/Girdin's modularity, interactome, and functions across invertebrates and vertebrates, revealing distinct roles in cancer as tumor suppressor or oncogene.

E-cigarettes compromise the gut barrier and trigger gut inflammation

This study shows that chronic e-cigarette use damages the gut barrier and causes inflammation, driven by non-nicotine chemicals in e-liquids.

A zebrafish model of Granulin deficiency reveals essential roles in myeloid cell differentiation

This study uses a zebrafish model of granulin deficiency to show granulin's role in myeloid cell differentiation and wound healing.

DNA glycosylase NEIL2 prevents Fusobacterium-mediated inflammation and DNA damage in colonic epithelial cells

This study shows that NEIL2, a DNA repair enzyme, is downregulated by Fusobacterium infection, leading to DNA damage and inflammation in colonic epithelial cells, and this effect is specific to microsatellite stable colorectal cancers.

The immunosuppression of macrophages underlies the cardioprotective effects of catestatin (CST)

This study shows that CST reduces hypertension and cardiac inflammation by suppressing macrophage activity in mice.

GIV-Kindlin interaction is required for Kindlin-Mediated Integrin Recognition and Activation

This paper shows that GIV binds Kindlin-2 to enhance integrin activation, promoting cell adhesion and invasion, and links this interaction to metastasis in tumor transcriptomics.

GIV/Girdin and Exo70 Constitute the Core of the Mammalian Polarized Exocytic Machinery

This paper identifies GIV/Girdin as the mammalian homolog of yeast Bem1p, showing it binds Exo70 and is essential for polarized exocytosis, matrix metalloprotease delivery, and cell invasion.

Molecular epidemiology of Japanese Encephalitis Virus in pig population of Odisha, Assam and Manipur states of India

This study investigates JEV prevalence and molecular epidemiology in pigs from three Indian states, finding higher infection rates in Manipur and identifying genotype III as dominant with specific mutations.

Computational approach to identifying universal macrophage biomarker

The paper identifies FCER1G and TYROBP as universal macrophage biomarkers using the BECC computational approach, validated across human and mouse tissues.

NEIL2 plays a critical role in limiting inflammation and preserving genomic integrity in H. pylori-infected gastric epithelial cells

This study shows that NEIL2 suppression by H. pylori infection leads to DNA damage accumulation, inflammation, and gastric cancer progression in mouse models and human cells.

Identification of histological features to predict MUC2 expression in colon cancer tissues

The paper identifies histological features, such as large nuclear area, associated with MUC2 expression in colon cancer tissues using TCGA data.

Convergence of Wnt, Growth Factor and Trimeric G protein signals on Daple

This study identifies Daple as a convergence point for Wnt, growth factor, and G-protein signaling in cancer, showing its role in tumor progression and poor prognosis in colorectal cancer.